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Immunity raised by recent European subtype 1 PRRSV strains allows better replication of East European subtype 3 PRRSV strain Lena than that raised by an older strain

Overview of attention for article published in Veterinary Research, January 2016
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Title
Immunity raised by recent European subtype 1 PRRSV strains allows better replication of East European subtype 3 PRRSV strain Lena than that raised by an older strain
Published in
Veterinary Research, January 2016
DOI 10.1186/s13567-015-0292-y
Pubmed ID
Authors

Ivan Trus, Ilias S. Frydas, Vishwanatha R. A. P. Reddy, Caroline Bonckaert, Yewei Li, Lise K. Kvisgaard, Lars E. Larsen, Hans J. Nauwynck

Abstract

Stable spatial distribution of porcine reproductive and respiratory syndrome (PRRSV)-1 subtypes in Europe is accompanied by a strong population immunity induced by local PRRSV strains. In the present study, it was examined if the immunity induced by three West European subtype 1 PRRSV strains (2007 isolate 07V063 and 2013 isolates 13V091 and 13V117) offers protection against the highly virulent East European subtype 3 PRRSV strain Lena. The number of fever days was greater (p < 0.05) in the control group (7.6 ± 1.7 days) compared to the immune groups (07V063-immune: 4.0 ± 1.2 days, 13V091-immune: 4.6 ± 1.1 days, 13V117-immune: 4.0 ± 2.9 days). In all groups, protection was characterized by reduction (p < 0.05) of AUC values of nasal shedding (control: 14.6, 07V063-immune: 3.4, 13V091-immune: 8.9, 13V117-immune: 8.0) and viremia (control: 28.1, 07V063-immune: 5.4, 13V091-immune: 9.0, 13V117-immune: 8.3). Reduction of respiratory disease, nasal shedding (mean AUC and mean peak values) and viremia (mean AUC and mean peak values) was more pronounced in 07V063-immune (p < 0.05) than in 13V091-immune and 13V117-immune animals. Inoculation with subtype 1 PRRSV strains caused priming of the Lena-specific virus neutralization antibody response. Upon challenge with Lena, we observed a very strong serological booster effect for neutralizing antibodies against strains used for the first inoculation. Our results indicate that inoculation with subtype 1 PRRSV strains can partially protect against antigenically divergent subtype 3 strains. The lower protection level elicited by recently isolated subtype 1 PRRSV strains may impair the outcome of the spatial expansion of subtype 3 strains from East Europe to West Europe.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 4%
Unknown 24 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 24%
Student > Ph. D. Student 4 16%
Student > Bachelor 3 12%
Student > Master 2 8%
Other 2 8%
Other 3 12%
Unknown 5 20%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 8 32%
Agricultural and Biological Sciences 4 16%
Immunology and Microbiology 3 12%
Biochemistry, Genetics and Molecular Biology 2 8%
Medicine and Dentistry 2 8%
Other 0 0%
Unknown 6 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 January 2016.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from Veterinary Research
#1,035
of 1,337 outputs
Outputs of similar age
#295,204
of 400,029 outputs
Outputs of similar age from Veterinary Research
#19
of 30 outputs
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