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Prognostic impact of H3K27me3 expression on locoregional progression after chemoradiotherapy in esophageal squamous cell carcinoma

Overview of attention for article published in BMC Cancer, December 2009
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Mentioned by

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1 tweeter

Citations

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48 Dimensions

Readers on

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35 Mendeley
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Title
Prognostic impact of H3K27me3 expression on locoregional progression after chemoradiotherapy in esophageal squamous cell carcinoma
Published in
BMC Cancer, December 2009
DOI 10.1186/1471-2407-9-461
Pubmed ID
Authors

Li-Ru He, Meng-Zhong Liu, Bin-Kui Li, Hui-Lan Rao, Yi-Ji Liao, Xin-Yuan Guan, Yi-Xin Zeng, Dan Xie

Abstract

Trimethylation of lysine 27 on histone H3 (H3K27me3) by enhancer of zeste homolog 2 (EZH2) is an epigenetic mark that mediates gene silencing. EZH2 is overexpressed and correlates with poor prognosis in many cancers. However, the clinical implication of H3K27me3 in human malignancies has not been well established. We wished to ascertain whether a correlation exists between the expression of H3K27me3 and clinical outcome in a group of patients with esophageal squamous cell carcinoma (ESCC) treated with definitive chemoradiotherapy (CRT).

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 35 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 29%
Researcher 7 20%
Student > Master 3 9%
Student > Doctoral Student 2 6%
Student > Bachelor 2 6%
Other 4 11%
Unknown 7 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 31%
Medicine and Dentistry 9 26%
Biochemistry, Genetics and Molecular Biology 6 17%
Nursing and Health Professions 1 3%
Engineering 1 3%
Other 0 0%
Unknown 7 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2011.
All research outputs
#2,018,322
of 3,627,464 outputs
Outputs from BMC Cancer
#894
of 1,786 outputs
Outputs of similar age
#100,054
of 231,320 outputs
Outputs of similar age from BMC Cancer
#48
of 87 outputs
Altmetric has tracked 3,627,464 research outputs across all sources so far. This one is in the 25th percentile – i.e., 25% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,786 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,320 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 87 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.