Title |
Serotonin transporter gene polymorphisms and brain function during emotional distraction from cognitive processing in posttraumatic stress disorder
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Published in |
BMC Psychiatry, May 2011
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DOI | 10.1186/1471-244x-11-76 |
Pubmed ID | |
Authors |
Rajendra A Morey, Ahmad R Hariri, Andrea L Gold, Michael A Hauser, Heidi J Munger, Florin Dolcos, Gregory McCarthy |
Abstract |
Serotonergic system dysfunction has been implicated in posttraumatic stress disorder (PTSD). Genetic polymorphisms associated with serotonin signaling may predict differences in brain circuitry involved in emotion processing and deficits associated with PTSD. In healthy individuals, common functional polymorphisms in the serotonin transporter gene (SLC6A4) have been shown to modulate amygdala and prefrontal cortex (PFC) activity in response to salient emotional stimuli. Similar patterns of differential neural responses to emotional stimuli have been demonstrated in PTSD but genetic factors influencing these activations have yet to be examined. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
Italy | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Sweden | 2 | 1% |
Germany | 1 | <1% |
United Kingdom | 1 | <1% |
Russia | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 184 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 33 | 17% |
Student > Bachelor | 27 | 14% |
Student > Ph. D. Student | 25 | 13% |
Student > Master | 19 | 10% |
Student > Doctoral Student | 13 | 7% |
Other | 37 | 19% |
Unknown | 37 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 68 | 36% |
Medicine and Dentistry | 28 | 15% |
Agricultural and Biological Sciences | 21 | 11% |
Neuroscience | 11 | 6% |
Biochemistry, Genetics and Molecular Biology | 7 | 4% |
Other | 17 | 9% |
Unknown | 39 | 20% |