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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Detection of low prevalence somatic mutations in solid tumors with ultra-deep targeted sequencing
|
|---|---|
| Published in |
Genome Biology, December 2011
|
| DOI | 10.1186/gb-2011-12-12-r124 |
| Pubmed ID | |
| Authors |
Olivier Harismendy, Richard B Schwab, Lei Bao, Jeff Olson, Sophie Rozenzhak, Steve K Kotsopoulos, Stephanie Pond, Brian Crain, Mark S Chee, Karen Messer, Darren R Link, Kelly A Frazer |
| Abstract |
Ultra-deep targeted sequencing (UDT-Seq) can identify subclonal somatic mutations in tumor samples. Early assays' limited breadth and depth restrict their clinical utility. Here, we target 71 kb of mutational hotspots in 42 cancer genes. We present novel methods enhancing both laboratory workflow and mutation detection. We evaluate UDT-Seq true sensitivity and specificity (> 94% and > 99%, respectively) for low prevalence mutations in a mixing experiment and demonstrate its utility using six tumor samples. With an improved performance when run on the Illumina Miseq, the UDT-Seq assay is well suited for clinical applications to guide therapy and study clonal selection in heterogeneous samples. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 33% |
| United States | 1 | 33% |
| India | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 201 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 10 | 5% |
| United States | 4 | 2% |
| Malaysia | 1 | <1% |
| Australia | 1 | <1% |
| Sweden | 1 | <1% |
| Canada | 1 | <1% |
| Chile | 1 | <1% |
| Singapore | 1 | <1% |
| Belarus | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 178 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 65 | 32% |
| Student > Ph. D. Student | 42 | 21% |
| Student > Master | 25 | 12% |
| Other | 16 | 8% |
| Professor > Associate Professor | 10 | 5% |
| Other | 30 | 15% |
| Unknown | 13 | 6% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 102 | 51% |
| Biochemistry, Genetics and Molecular Biology | 29 | 14% |
| Medicine and Dentistry | 28 | 14% |
| Computer Science | 10 | 5% |
| Engineering | 7 | 3% |
| Other | 10 | 5% |
| Unknown | 15 | 7% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 August 2023.
All research outputs
#6,373,631
of 25,374,647 outputs
Outputs from Genome Biology
#3,049
of 4,467 outputs
Outputs of similar age
#51,740
of 248,898 outputs
Outputs of similar age from Genome Biology
#26
of 41 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 248,898 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.