Title |
Morphometic analysis of TCGA glioblastoma multiforme
|
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Published in |
BMC Bioinformatics, December 2011
|
DOI | 10.1186/1471-2105-12-484 |
Pubmed ID | |
Authors |
Hang Chang, Gerald V Fontenay, Ju Han, Ge Cong, Frederick L Baehner, Joe W Gray, Paul T Spellman, Bahram Parvin |
Abstract |
Our goals are to develop a computational histopathology pipeline for characterizing tumor types that are being generated by The Cancer Genome Atlas (TCGA) for genomic association. TCGA is a national collaborative program where different tumor types are being collected, and each tumor is being characterized using a variety of genome-wide platforms. Here, we have developed a tumor-centric analytical pipeline to process tissue sections stained with hematoxylin and eosin (H&E) for visualization and cell-by-cell quantitative analysis. Thus far, analysis is limited to Glioblastoma Multiforme (GBM) and kidney renal clear cell carcinoma tissue sections. The final results are being distributed for subtyping and linking the histology sections to the genomic data. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 4% |
Germany | 2 | 2% |
Brazil | 2 | 2% |
Colombia | 1 | 1% |
Spain | 1 | 1% |
United Kingdom | 1 | 1% |
Unknown | 79 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 24 | 27% |
Student > Ph. D. Student | 22 | 24% |
Student > Master | 9 | 10% |
Student > Bachelor | 6 | 7% |
Professor > Associate Professor | 6 | 7% |
Other | 16 | 18% |
Unknown | 7 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Computer Science | 19 | 21% |
Biochemistry, Genetics and Molecular Biology | 15 | 17% |
Agricultural and Biological Sciences | 15 | 17% |
Medicine and Dentistry | 13 | 14% |
Engineering | 8 | 9% |
Other | 7 | 8% |
Unknown | 13 | 14% |