Title |
The impact of taxane-based preoperative chemotherapy in gastroesophageal signet ring cell adenocarcinomas
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Published in |
Journal of Hematology & Oncology, May 2015
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DOI | 10.1186/s13045-015-0148-y |
Pubmed ID | |
Authors |
Stefano Kim, Frederic Fiteni, Sophie Paget-Bailly, François Ghiringhelli, Zaher Lakkis, Marine Jary, Francine Fein, Franck Bonnetain, Christophe Mariette, Christophe Borg |
Abstract |
The benefit of preoperative chemotherapy in resectable gastroesophageal adenocarcinomas was not observed in signet ring cell subtype. However, the potential interest of taxane-based preoperative chemotherapy on this subtype is still an unresolved issue. Nineteen patients with localized signet ring cell adenocarcinomas received taxane-based regimens, and 17 patients underwent surgery. Complete resection was achieved in 80 %, and median overall survival was 40.8 months (95 % confidence interval (CI), 20.2-not reached). Even though one patient achieved a complete pathological response, seven patients had an upstaging of their tumors at surgery. The potential benefits of taxane-based chemotherapy seem to be limited to a reduced number of patients. |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Poland | 1 | 8% |
Unknown | 11 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 2 | 17% |
Unspecified | 1 | 8% |
Other | 1 | 8% |
Librarian | 1 | 8% |
Researcher | 1 | 8% |
Other | 1 | 8% |
Unknown | 5 | 42% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 4 | 33% |
Unspecified | 1 | 8% |
Immunology and Microbiology | 1 | 8% |
Economics, Econometrics and Finance | 1 | 8% |
Unknown | 5 | 42% |