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Individualized ranibizumab therapy strategies in year 3 after as-needed treatment for polypoidal choroidal vasculopathy

Overview of attention for article published in BMC Ophthalmology, April 2015
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Title
Individualized ranibizumab therapy strategies in year 3 after as-needed treatment for polypoidal choroidal vasculopathy
Published in
BMC Ophthalmology, April 2015
DOI 10.1186/s12886-015-0026-y
Pubmed ID
Authors

Taiichi Hikichi

Abstract

To investigate the third-year results of ranibizumab monotherapy for polypoidal choroidal vasculopathy (PCV) in individualized treatment regimens based on the outcomes during 2 years. One hundred seventy-two consecutive eyes of 163 prospective treatment-naïve patients with PCV were treated with three monthly intravitreal ranibizumab injections followed by as-needed reinjections and completed a 2-year follow-up. Treatment regimens during the third year were selected individually based on their outcomes from the following treatment regimens: as-needed injections based on quarterly examinations, as-needed injections based on monthly examinations, a monthly ranibizumab injection schedule, and the treat-and-extend schedule. Visual acuity (VA) and foveal thickness at the end of the third year and the prevalence of discontinuous follow-up examinations during the third year were evaluated. Of 163 patients, 35 (21%) patients were excluded; nine patients had discontinuous follow-up examinations during the third year. In 128 eyes of 128 patients studied during the third year, the significant improvements in VA and foveal thickness 2 years after the first injection compared to baseline were maintained at the end of the third year. Six (18%, 6/34) patients treated with as-needed injections based on quarterly examinations had discontinuous follow-up examinations, the prevalence of which differed significantly (P = 0.025) from the other groups. The individualized treatment strategies in the third year based on each patient's outcomes during 2 years maintained the improved VA and avoided discontinuation of follow-up during the third year.

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Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Other 1 14%
Student > Master 1 14%
Researcher 1 14%
Professor > Associate Professor 1 14%
Student > Postgraduate 1 14%
Other 0 0%
Unknown 2 29%
Readers by discipline Count As %
Medicine and Dentistry 2 29%
Nursing and Health Professions 1 14%
Pharmacology, Toxicology and Pharmaceutical Science 1 14%
Unknown 3 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2016.
All research outputs
#20,302,535
of 22,840,638 outputs
Outputs from BMC Ophthalmology
#2,084
of 2,347 outputs
Outputs of similar age
#223,231
of 264,143 outputs
Outputs of similar age from BMC Ophthalmology
#21
of 31 outputs
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