Title |
Graph based fusion of miRNA and mRNA expression data improves clinical outcome prediction in prostate cancer
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Published in |
BMC Bioinformatics, December 2011
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DOI | 10.1186/1471-2105-12-488 |
Pubmed ID | |
Authors |
Stephan Gade, Christine Porzelius, Maria Fälth, Jan C Brase, Daniela Wuttig, Ruprecht Kuner, Harald Binder, Holger Sültmann, Tim Beißbarth |
Abstract |
One of the main goals in cancer studies including high-throughput microRNA (miRNA) and mRNA data is to find and assess prognostic signatures capable of predicting clinical outcome. Both mRNA and miRNA expression changes in cancer diseases are described to reflect clinical characteristics like staging and prognosis. Furthermore, miRNA abundance can directly affect target transcripts and translation in tumor cells. Prediction models are trained to identify either mRNA or miRNA signatures for patient stratification. With the increasing number of microarray studies collecting mRNA and miRNA from the same patient cohort there is a need for statistical methods to integrate or fuse both kinds of data into one prediction model in order to find a combined signature that improves the prediction. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 50% |
France | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 1% |
Ukraine | 1 | 1% |
Slovenia | 1 | 1% |
Mexico | 1 | 1% |
United States | 1 | 1% |
Unknown | 69 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 22 | 30% |
Researcher | 16 | 22% |
Student > Master | 10 | 14% |
Student > Bachelor | 8 | 11% |
Professor > Associate Professor | 6 | 8% |
Other | 9 | 12% |
Unknown | 3 | 4% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 24 | 32% |
Computer Science | 22 | 30% |
Biochemistry, Genetics and Molecular Biology | 5 | 7% |
Engineering | 5 | 7% |
Mathematics | 4 | 5% |
Other | 8 | 11% |
Unknown | 6 | 8% |