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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Maternal B vitamins: effects on offspring weight and DNA methylation at genomically imprinted domains
|
|---|---|
| Published in |
Clinical Epigenetics, January 2016
|
| DOI | 10.1186/s13148-016-0174-9 |
| Pubmed ID | |
| Authors |
Lauren E. McCullough, Erline E. Miller, Michelle A. Mendez, Amy P. Murtha, Susan K. Murphy, Cathrine Hoyo |
| Abstract |
Inadequate maternal nutrition during early fetal development can create permanent alterations in the offspring, leading to poor health outcomes. While nutrients involved in one-carbon cycle metabolism are important to fetal growth, associations with specific nutrients remain inconsistent. This study estimates associations between maternal vitamins B12, B6 (pyridoxal phosphate [PLP] and 4-pyridoxic acid [PA]), and homocysteine (Hcy) concentrations, offspring weight (birth weight and 3-year weight gain), and DNA methylation at four differentially methylated regions (DMRs) known to be involved in fetal growth and development (H19, MEG3, SGCE/PEG10, and PLAGL1). Study participants (n = 496) with biomarker and birth weight data were enrolled as part of the Newborn Epigenetics STudy. Weight gain data were available for 273 offspring. Among 484 mother-infant pairs, DNA methylation at regulatory sequences of genomically imprinted genes was measured in umbilical cord blood DNA using bisulfite pyrosequencing. We used generalized linear models to estimate associations. Multivariate adjusted regression models revealed an inverse association between maternal Hcy concentration and male birth weight (β = -210.40, standard error (SE) = 102.08, p = 0.04). The offspring of the mothers in the highest quartile of B12 experienced lower weight gain between birth and 3 years compared to the offspring of the mothers in the lowest (β = -2203.03, SE = 722.49, p = 0.003). Conversely, maternal PLP was associated with higher weight gain in males; higher maternal PLP concentrations were also associated with offspring DNA methylation levels at the MEG3 DMR (p < 0.01). While maternal concentrations of B12, B6, and Hcy do not associate with birth weight overall, they may play an important role in 3-year weight gain. This is the first study to report an association between maternal PLP and methylation at the MEG3 DMR which may be an important epigenetic tag for maternal B vitamin adequacy. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 22% |
| United States | 2 | 22% |
| Australia | 1 | 11% |
| France | 1 | 11% |
| Unknown | 3 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 78% |
| Scientists | 2 | 22% |
Mendeley readers
The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| Norway | 1 | <1% |
| Unknown | 114 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 20% |
| Student > Master | 15 | 13% |
| Researcher | 14 | 12% |
| Student > Bachelor | 11 | 9% |
| Student > Doctoral Student | 10 | 9% |
| Other | 21 | 18% |
| Unknown | 22 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 34 | 29% |
| Biochemistry, Genetics and Molecular Biology | 16 | 14% |
| Agricultural and Biological Sciences | 14 | 12% |
| Nursing and Health Professions | 9 | 8% |
| Psychology | 4 | 3% |
| Other | 11 | 9% |
| Unknown | 28 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 January 2016.
All research outputs
#5,840,877
of 23,342,092 outputs
Outputs from Clinical Epigenetics
#379
of 1,291 outputs
Outputs of similar age
#93,425
of 397,709 outputs
Outputs of similar age from Clinical Epigenetics
#21
of 54 outputs
Altmetric has tracked 23,342,092 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 1,291 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 397,709 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.