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Mendeley readers
Attention Score in Context
| Title |
Increased production of inosine and guanosine by means of metabolic engineering of the purine pathway in Ashbya gossypii
|
|---|---|
| Published in |
Microbial Cell Factories, April 2015
|
| DOI | 10.1186/s12934-015-0234-4 |
| Pubmed ID | |
| Authors |
Rodrigo Ledesma-Amaro, Ruben M Buey, Jose Luis Revuelta |
| Abstract |
Inosine and guanosine monophosphate nucleotides are convenient sources of the umami flavor, with attributed beneficial health effects that have renewed commercial interest in nucleotide fermentations. Accordingly, several bacterial strains that excrete high levels of inosine and guanosine nucleosides are currently used in the food industry for this purpose. In the present study, we show that the filamentous fungus Ashbya gossypii, a natural riboflavin overproducer, excretes high amounts of inosine and guanosine nucleosides to the culture medium. Following a rational metabolic engineering approach of the de novo purine nucleotide biosynthetic pathway, we increased the excreted levels of inosine up to 27-fold. We generated Ashbya gossypii strains with improved production titers of inosine and guanosine. Our results point to Ashbya gossypii as the first eukaryotic microorganism as a promising candidate, susceptible to further manipulation, for industrial nucleoside fermentation. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 1 | 2% |
| Unknown | 60 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 26% |
| Student > Master | 7 | 11% |
| Student > Bachelor | 7 | 11% |
| Student > Ph. D. Student | 5 | 8% |
| Other | 4 | 7% |
| Other | 11 | 18% |
| Unknown | 11 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 19 | 31% |
| Agricultural and Biological Sciences | 18 | 30% |
| Chemistry | 5 | 8% |
| Engineering | 2 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Other | 5 | 8% |
| Unknown | 11 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 March 2021.
All research outputs
#5,459,449
of 22,840,638 outputs
Outputs from Microbial Cell Factories
#355
of 1,602 outputs
Outputs of similar age
#63,545
of 264,802 outputs
Outputs of similar age from Microbial Cell Factories
#6
of 37 outputs
Altmetric has tracked 22,840,638 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,602 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,802 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.