Title |
Loss of nuclear localization of TET2 in colorectal cancer
|
---|---|
Published in |
Clinical Epigenetics, January 2016
|
DOI | 10.1186/s13148-016-0176-7 |
Pubmed ID | |
Authors |
Yuji Huang, Guanghui Wang, Zhonglin Liang, Yili Yang, Long Cui, Chen-Ying Liu |
Abstract |
5-Hydroxymethylcytosine (5hmC) is lost in multiple human cancers, including colorectal cancer (CRC). Decreased ten-eleven translocation 1 (TET1) messenger RNA (mRNA), but not other two TET family members, has been observed in the colorectal cancer and is crucial for colorectal cancer initiation. Here, we show that nuclear localization of TET2 was lost in a significant portion of CRC tissues, in association with metastasis. In CRC cells, nuclear expression of TET2 were absent but not TET3. Nuclear export inhibitor can increase the 5hmC level in CRC cells, probably through regulating TET2. Our results indicate a new mechanism of TET2 dysregulation in colorectal cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 33% |
United Kingdom | 2 | 22% |
Brazil | 1 | 11% |
Canada | 1 | 11% |
Unknown | 2 | 22% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 56% |
Scientists | 3 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 54 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 18 | 33% |
Student > Master | 13 | 24% |
Researcher | 6 | 11% |
Student > Bachelor | 3 | 6% |
Professor > Associate Professor | 3 | 6% |
Other | 4 | 7% |
Unknown | 7 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 24 | 44% |
Agricultural and Biological Sciences | 14 | 26% |
Medicine and Dentistry | 4 | 7% |
Nursing and Health Professions | 1 | 2% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 2 | 4% |
Unknown | 8 | 15% |