Title |
Absence of human rhinovirus and respiratory syncytial virus from bronchoalveolar lavage and bronchial biopsies of selected patients with stable chronic obstructive pulmonary disease
|
---|---|
Published in |
Respiratory Research, January 2016
|
DOI | 10.1186/s12931-016-0323-x |
Pubmed ID | |
Authors |
Styliani Giannakaki, Lida Politi, Elvira Markella Antonogiannaki, Nick Spanakis, Georgios Arsenis, Vasiliki Filaditaki, Spyridon Zakynthinos, Napoleon Karagiannidis, Athanassios Tsakris |
Abstract |
Previous studies have reported very different rates of human rhinovirus (HRV) and respiratory syncytial virus (RSV) genome detection in nasal and sputum samples, but not in bronchoalveolar lavage (BAL) and bronchial biopsy samples. Our study aimed to investigate the presence of HRV and RSV in the lungs of 31 consecutive patients with stable COPD (11 GOLD stage I, 11 II, and 9 III) and 22 control subjects (12 current or past smokers, and 10 non-smokers), who underwent diagnostic (e.g., lung cancer) and/or therapeutic (e.g., hemoptysis) fibreoptic bronchoscopy in a university hospital in Athens, Greece. Viral RNA of HRV and RSV were not detected in any of the samples of COPD patients or control subjects after being processed with real-time PCR. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 26 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 4 | 15% |
Researcher | 3 | 12% |
Other | 2 | 8% |
Professor | 2 | 8% |
Student > Doctoral Student | 1 | 4% |
Other | 4 | 15% |
Unknown | 10 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 23% |
Nursing and Health Professions | 2 | 8% |
Immunology and Microbiology | 2 | 8% |
Agricultural and Biological Sciences | 1 | 4% |
Unspecified | 1 | 4% |
Other | 5 | 19% |
Unknown | 9 | 35% |