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Genomic profiling of lower-grade gliomas uncovers cohesive disease groups: implications for diagnosis and treatment

Overview of attention for article published in Ai zheng Aizheng Chinese journal of cancer, January 2016
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About this Attention Score

  • Among the highest-scoring outputs from this source (#37 of 231)
  • Good Attention Score compared to outputs of the same age (71st percentile)

Mentioned by

twitter
7 tweeters

Citations

dimensions_citation
17 Dimensions

Readers on

mendeley
22 Mendeley
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Title
Genomic profiling of lower-grade gliomas uncovers cohesive disease groups: implications for diagnosis and treatment
Published in
Ai zheng Aizheng Chinese journal of cancer, January 2016
DOI 10.1186/s40880-015-0071-1
Pubmed ID
Authors

Chang-Ming Zhang, Daniel J. Brat

Abstract

Lower-grade gliomas (including low- and intermediate-grade gliomas, World Health Organization grades II and III) are diffusely infiltrative neoplasms that arise most often in the cerebral hemispheres of adults and have traditionally been classified based on their presumed histogenesis as astrocytomas, oligodendrogliomas, or oligoastrocytomas. Although the histopathologic classification of lower-grade glioma has been the accepted standard for nearly a century, it suffers from high intra- and inter-observer variability and does not adequately predict clinical outcomes. Based on integrated analysis of multiplatform genomic data from The Cancer Genome Atlas, lower-grade gliomas have been found to segregate into three cohesive, clinically relevant molecular classes. Molecular classes were closely aligned with the status of isocitrate dehydrogenase (IDH) mutations, tumor protein 53 mutations and the co-deletion of chromosome arms 1p and 19q, but were not closely aligned with histologic classes. These findings emphasize the potential for improved definition of clinically relevant disease subsets using integrated molecular approaches and highlight the importance of biomarkers for brain tumor classification.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Other 7 32%
Student > Master 4 18%
Student > Bachelor 3 14%
Researcher 2 9%
Student > Postgraduate 2 9%
Other 3 14%
Unknown 1 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 27%
Medicine and Dentistry 5 23%
Biochemistry, Genetics and Molecular Biology 4 18%
Neuroscience 2 9%
Psychology 1 5%
Other 2 9%
Unknown 2 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 June 2016.
All research outputs
#4,828,036
of 16,471,689 outputs
Outputs from Ai zheng Aizheng Chinese journal of cancer
#37
of 231 outputs
Outputs of similar age
#96,716
of 346,473 outputs
Outputs of similar age from Ai zheng Aizheng Chinese journal of cancer
#1
of 1 outputs
Altmetric has tracked 16,471,689 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 231 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 346,473 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them