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Peroxiredoxin 4: a multifunctional biomarker worthy of further exploration

Overview of attention for article published in BMC Medicine, December 2011
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1 tweeter

Citations

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32 Mendeley
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Title
Peroxiredoxin 4: a multifunctional biomarker worthy of further exploration
Published in
BMC Medicine, December 2011
DOI 10.1186/1741-7015-9-137
Pubmed ID
Authors

Janin Schulte

Abstract

Currently, there is much interest in identifying clinically relevant biomarkers, as they have the potential to be high utility non-invasive tools for early diagnosis and reliable patient monitoring in numerous conditions. Since its discovery almost 15 years ago, research on the ubiquitous antioxidant enzyme peroxiredoxin 4 (Prx4) has culminated in the recognition that Prx4 levels are different in blood drawn from the healthy general population and patients with acute or chronic diseases. In this commentary, the most striking research data from different in vitro approaches, animal models and human observational studies are discussed collectively, highlighting the clinical importance of Prx4 as a multifunctional staging and prognosis biomarker. In this context, the oxidative state of patients may be reflected by intra- and extracellular Prx4 levels, redox state, oligomerization and nitro-oxidative modifications of the enzyme. A consolidated model of the potential role and origin of circulating Prx4 is presented to stimulate further investigations in light of the current biomarker situation.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 3%
Canada 1 3%
Unknown 30 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 19%
Researcher 6 19%
Student > Bachelor 5 16%
Student > Ph. D. Student 4 13%
Other 2 6%
Other 8 25%
Unknown 1 3%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 38%
Biochemistry, Genetics and Molecular Biology 10 31%
Medicine and Dentistry 5 16%
Environmental Science 1 3%
Immunology and Microbiology 1 3%
Other 1 3%
Unknown 2 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2012.
All research outputs
#10,336,599
of 12,954,230 outputs
Outputs from BMC Medicine
#1,963
of 2,068 outputs
Outputs of similar age
#151,982
of 214,015 outputs
Outputs of similar age from BMC Medicine
#102
of 115 outputs
Altmetric has tracked 12,954,230 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,068 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 34.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 214,015 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 115 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.