Title |
Paraproteinemic neuropathy: a practical review
|
---|---|
Published in |
BMC Neurology, January 2016
|
DOI | 10.1186/s12883-016-0532-4 |
Pubmed ID | |
Authors |
Richard A. Rison, Said R. Beydoun |
Abstract |
The term paraproteinemic neuropathy describes a heterogeneous set of neuropathies characterized by the presence of homogeneous immunoglobulin in the serum. An abnormal clonal proliferation of B-lymphocytes or plasma cells, which may or may not occur in the context of a hematologic malignancy, produces the immunoglobulins in excess. If malignancy is identified, treatment should be targeted to the neoplasm. Most cases, however, occur as monoclonal gammopathy of undetermined significance. Few prospective, randomized, placebo-controlled trials are available to inform the management of paraproteinemic neuropathies. Clinical experience combined with data from smaller, uncontrolled studies provide a basis for recommendations, which depend on the specific clinical setting in which the paraprotein occurs. In this review, we provide a clinically practical approach to diagnosis and management of such patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 38% |
Egypt | 1 | 13% |
Ecuador | 1 | 13% |
Brazil | 1 | 13% |
Unknown | 2 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 75% |
Scientists | 1 | 13% |
Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 192 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 40 | 21% |
Researcher | 22 | 11% |
Student > Master | 20 | 10% |
Student > Postgraduate | 17 | 9% |
Student > Doctoral Student | 13 | 7% |
Other | 44 | 23% |
Unknown | 36 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 105 | 55% |
Neuroscience | 17 | 9% |
Nursing and Health Professions | 9 | 5% |
Biochemistry, Genetics and Molecular Biology | 5 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
Other | 9 | 5% |
Unknown | 44 | 23% |