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Characterization of ceftriaxone-resistant Aeromonas spp. isolates from stool samples of both children and adults in Southern India

Overview of attention for article published in Journal of Health, Population and Nutrition, December 2015
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Title
Characterization of ceftriaxone-resistant Aeromonas spp. isolates from stool samples of both children and adults in Southern India
Published in
Journal of Health, Population and Nutrition, December 2015
DOI 10.1186/s41043-015-0036-7
Pubmed ID
Authors

Maanasa Bhaskar, K P Dinoop, Jharna Mandal

Abstract

Aeromonas species can cause a wide spectrum of illnesses varying from intestinal to extra intestinal and vary in their susceptibility to different antibiotics. The current study was undertaken to characterize the third generation cephalosporin-resistant strains of Aeromonas spp. which were isolated from stool specimens. Out of a total of 2780 stool samples, 29 Aeromonas spp. were identified, out of which, 9 were resistant to ceftriaxone by the Kirby-Bauer antibiotic testing method. These strains were subjected to minimum inhibitory concentration (MIC) determination by agar dilution for ceftriaxone. Phenotypic and genotypic testing of AmpC beta-lactamase and extended spectrum beta-lactamase (ESBL) were performed. Gene transfer was carried out to demonstrate transmissibility of these genetic elements by conjugation experiments. Out of the 29 strains, 9 showed MIC of ≥4 μg/ml. Seven out of 9 showed presence of blaCTX-M, while 2 more strains showed the presence of inducible AmpC beta-lactamase and presence of MOX gene. Gene transfer experiments showed that these elements were transmissible to recipient (Escherichia coli J53 strain) in the presence of ceftriaxone. Dissemination of these resistance determinants like plasmids is pivotal in the spread of these resistance genes into the aquatic environment into organisms like Aeromonas. This may further limit the future use of antibiotics for the treatment of diarrhoeal diseases. Hence, detection and antibiotic susceptibility testing of Aeromonas spp. should be performed when isolated from stool samples.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 21%
Student > Ph. D. Student 6 18%
Student > Master 3 9%
Other 3 9%
Student > Postgraduate 2 6%
Other 3 9%
Unknown 10 29%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 18%
Immunology and Microbiology 5 15%
Biochemistry, Genetics and Molecular Biology 4 12%
Veterinary Science and Veterinary Medicine 3 9%
Medicine and Dentistry 2 6%
Other 2 6%
Unknown 12 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 January 2016.
All research outputs
#20,656,820
of 25,374,917 outputs
Outputs from Journal of Health, Population and Nutrition
#471
of 622 outputs
Outputs of similar age
#291,514
of 395,421 outputs
Outputs of similar age from Journal of Health, Population and Nutrition
#5
of 5 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 622 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
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