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Efficacy and safety of Maekmoondong-tang for chronic dry cough: a study protocol for a randomized controlled trial

Overview of attention for article published in BMC Complementary Medicine and Therapies, February 2016
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Title
Efficacy and safety of Maekmoondong-tang for chronic dry cough: a study protocol for a randomized controlled trial
Published in
BMC Complementary Medicine and Therapies, February 2016
DOI 10.1186/s12906-016-1028-x
Pubmed ID
Authors

Kwan-Il Kim, Seungwon Shin, Kyuseok Kim, Junhee Lee

Abstract

Chronic cough, defined it lasts more than 8 weeks. The symptom is common, but highly troublesome, and it reduces quality of life. Despite much effort to develop a protocol for diagnosis and treatment of chronic cough, it remains problematic to determine its cause. As a result, treatment is often unsuccessful. Thus, there is much interest regarding the use of symptomatic drugs to control chronic cough. Maekmoondong-tang is widely used in East Asian countries to treat chronic dry cough. Several experimental studies have reported that the herbal medicine has immunomodulatory and antitussive effects. Clinical studies involving Maekmoondong-tang have also been carried out; however, these studies have involved treating various diseases as a whole rather than chronic cough itself. Thus, we aim to evaluate the efficacy and safety of Maekmoondong-tang in chronic dry cough patients with a randomized controlled trial. This study is designed as an exploratory, single-center, placebo-controlled, double-blind, randomized, parallel group clinical trial. Patients with dry cough that has lasted more than 8 weeks will be recruited, after a 1-week run-in period, and randomly allocated to either the Maekmoondong-tang treatment group or the placebo group. The patients will receive Maekmoondong-tang or placebo granules 3 times daily for 4 weeks, with a 2-week follow-up. The primary outcome is a 10-point cough diary that will be recorded on a daily basis. The secondary outcomes comprise a cough visual analog scale, the Leicester Cough Questionnaire (Korean version), the Pattern Identification for Chronic Cough Questionnaire, biomarkers, safety testing, etc. Adverse events will also be reported. This trial will assess the efficacy and safety of Maekmoondong-tang in chronic dry cough. Korean Clinical Trial Registry ( http://cris.nih.go.kr ; registration number: KCT0001646). Date of registration: October 5 2015.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 2%
Unknown 46 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 13%
Student > Bachelor 4 9%
Unspecified 3 6%
Lecturer 3 6%
Researcher 3 6%
Other 13 28%
Unknown 15 32%
Readers by discipline Count As %
Medicine and Dentistry 10 21%
Nursing and Health Professions 4 9%
Pharmacology, Toxicology and Pharmaceutical Science 3 6%
Unspecified 3 6%
Economics, Econometrics and Finance 2 4%
Other 7 15%
Unknown 18 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 September 2016.
All research outputs
#14,834,028
of 22,842,950 outputs
Outputs from BMC Complementary Medicine and Therapies
#1,843
of 3,631 outputs
Outputs of similar age
#221,486
of 397,125 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#40
of 78 outputs
Altmetric has tracked 22,842,950 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,631 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 397,125 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.