Title |
Targeting autophagy to sensitive glioma to temozolomide treatment
|
---|---|
Published in |
Journal of Experimental & Clinical Cancer Research, February 2016
|
DOI | 10.1186/s13046-016-0303-5 |
Pubmed ID | |
Authors |
Yuanliang Yan, Zhijie Xu, Shuang Dai, Long Qian, Lunquan Sun, Zhicheng Gong |
Abstract |
Temozolomide (TMZ), an alkylating agent, is widely used for treating primary and recurrent high-grade gliomas. However, the efficacy of TMZ is often limited by the development of resistance. Recently, studies have found that TMZ treatment could induce autophagy, which contributes to therapy resistance in glioma. To enhance the benefit of TMZ in the treatment of glioblastomas, effective combination strategies are needed to sensitize glioblastoma cells to TMZ. In this regard, as autophagy could promote cell survival or autophagic cell death, modulating autophagy using a pharmacological inhibitor, such as chloroquine, or an inducer, such as rapamycin, has received considerably more attention. To understand the effectiveness of regulating autophagy in glioblastoma treatment, this review summarizes reports on glioblastoma treatments with TMZ and autophagic modulators from in vitro and in vivo studies, as well as clinical trials. Additionally, we discuss the possibility of using autophagy regulatory compounds that can sensitive TMZ treatment as a chemotherapy for glioma treatment. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 201 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 28 | 14% |
Student > Master | 28 | 14% |
Student > Bachelor | 26 | 13% |
Student > Ph. D. Student | 23 | 11% |
Student > Doctoral Student | 15 | 7% |
Other | 28 | 14% |
Unknown | 53 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 51 | 25% |
Agricultural and Biological Sciences | 28 | 14% |
Medicine and Dentistry | 25 | 12% |
Neuroscience | 11 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 9 | 4% |
Other | 18 | 9% |
Unknown | 59 | 29% |