Title |
Indispensable roles of OX40L-derived signal and epistatic genetic effect in immune-mediated pathogenesis of spontaneous pulmonary hypertension
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Published in |
BMC Immunology, December 2011
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DOI | 10.1186/1471-2172-12-67 |
Pubmed ID | |
Authors |
Moloud Rabieyousefi, Pejman Soroosh, Kimio Satoh, Fumiko Date, Naoto Ishii, Masahiro Yamashita, Masahiko Oka, Ivan F McMurtry, Hiroaki Shimokawa, Masato Nose, Kazuo Sugamura, Masao Ono |
Abstract |
Pulmonary hypertension (PH) refers to a spectrum of diseases with elevated pulmonary artery pressure. Pulmonary arterial hypertension (PAH) is a disease category that clinically presents with severe PH and that is histopathologically characterized by the occlusion of pulmonary arterioles, medial muscular hypertrophy, and/or intimal fibrosis. PAH occurs with a secondary as well as a primary onset. Secondary PAH is known to be complicated with immunological disorders. The aim of the present study is to histopathologically and genetically characterize a new animal model of PAH and clarify the role of OX40 ligand in the pathogenesis of PAH. |
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Demographic breakdown
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