Title |
Antiviral activity of four types of bioflavonoid against dengue virus type-2
|
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Published in |
Virology Journal, December 2011
|
DOI | 10.1186/1743-422x-8-560 |
Pubmed ID | |
Authors |
Keivan Zandi, Boon-Teong Teoh, Sing-Sin Sam, Pooi-Fong Wong, Mohd Rais Mustafa, Sazaly AbuBakar |
Abstract |
Dengue is a major mosquito-borne disease currently with no effective antiviral or vaccine available. Effort to find antivirals for it has focused on bioflavonoids, a plant-derived polyphenolic compounds with many potential health benefits. In the present study, antiviral activity of four types of bioflavonoid against dengue virus type -2 (DENV-2) in Vero cell was evaluated. Anti-dengue activity of these compounds was determined at different stages of DENV-2 infection and replication cycle. DENV replication was measured by Foci Forming Unit Reduction Assay (FFURA) and quantitative RT-PCR. Selectivity Index value (SI) was determined as the ratio of cytotoxic concentration 50 (CC50) to inhibitory concentration 50 (IC50) for each compound. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 21% |
France | 1 | 7% |
Switzerland | 1 | 7% |
Philippines | 1 | 7% |
Unknown | 8 | 57% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 12 | 86% |
Practitioners (doctors, other healthcare professionals) | 1 | 7% |
Scientists | 1 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | <1% |
Switzerland | 1 | <1% |
Indonesia | 1 | <1% |
Italy | 1 | <1% |
Costa Rica | 1 | <1% |
Unknown | 462 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 82 | 18% |
Student > Bachelor | 73 | 16% |
Student > Ph. D. Student | 66 | 14% |
Researcher | 45 | 10% |
Student > Doctoral Student | 21 | 4% |
Other | 53 | 11% |
Unknown | 127 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 76 | 16% |
Biochemistry, Genetics and Molecular Biology | 63 | 13% |
Chemistry | 50 | 11% |
Medicine and Dentistry | 41 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 30 | 6% |
Other | 66 | 14% |
Unknown | 141 | 30% |