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Mendeley readers
| Title |
Predictors of immune reconstitution inflammatory syndrome associated with Kaposi’s sarcoma: a case report
|
|---|---|
| Published in |
Infectious Agents and Cancer, February 2016
|
| DOI | 10.1186/s13027-016-0051-3 |
| Pubmed ID | |
| Authors |
Anna Maria Cattelan, Adriana Mattiolo, Angela Grassi, Maria Assunta Piano, Lolita Sasset, Marco Trevenzoli, Paola Zanovello, Maria Luisa Calabrò |
| Abstract |
We present here a case of immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma (KS-IRIS) developed in an AIDS patient two months after initiation of antiretroviral therapy (ART). Baseline characteristics of this IRIS-KS case, within a cohort of 12 naïve AIDS-KS patients, were analyzed. No statistically significant differences in CD4 cell counts, plasma HIV RNA load, KS clinical staging, human herpesvirus 8 (HHV8) antibody titers and HHV8 load in peripheral blood mononuclear cells and saliva were evidenced. HHV8 load in plasma was found to be significantly higher in the KS-IRIS patient (> 6 log10 genome equivalents/ml, p = 0.01, t-test) compared to the 11 patients with KS regression. This case highlights that measurement of HHV8 load in plasma may be useful to identify patients at risk for KS-IRIS, and that this parameter should be included in the design of larger studies to define KS-IRIS risk predictors. |
Mendeley readers
The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Argentina | 1 | 6% |
| Unknown | 15 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 4 | 25% |
| Student > Ph. D. Student | 4 | 25% |
| Professor | 2 | 13% |
| Other | 1 | 6% |
| Librarian | 1 | 6% |
| Other | 2 | 13% |
| Unknown | 2 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 56% |
| Agricultural and Biological Sciences | 2 | 13% |
| Nursing and Health Professions | 2 | 13% |
| Immunology and Microbiology | 1 | 6% |
| Computer Science | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 1 | 6% |