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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Characterization of chromatin accessibility with a transposome hypersensitive sites sequencing (THS-seq) assay
|
|---|---|
| Published in |
Genome Biology, February 2016
|
| DOI | 10.1186/s13059-016-0882-7 |
| Pubmed ID | |
| Authors |
Brandon Chin Sos, Ho-Lim Fung, Derek Rui Gao, Trina Faye Osothprarop, Amirali Kia, Molly Min He, Kun Zhang |
| Abstract |
Chromatin accessibility captures in vivo protein-chromosome binding status, and is considered an informative proxy for protein-DNA interactions. DNase I and Tn5 transposase assays require thousands to millions of fresh cells for comprehensive chromatin mapping. Applying Tn5 tagmentation to hundreds of cells results in sparse chromatin maps. We present a transposome hypersensitive sites sequencing assay for highly sensitive characterization of chromatin accessibility. Linear amplification of accessible DNA ends with in vitro transcription, coupled with an engineered Tn5 super-mutant, demonstrates improved sensitivity on limited input materials, and accessibility of small regions near distal enhancers, compared with ATAC-seq. |
X Demographics
The data shown below were collected from the profiles of 45 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 12 | 27% |
| United Kingdom | 11 | 24% |
| Australia | 6 | 13% |
| Denmark | 1 | 2% |
| Canada | 1 | 2% |
| France | 1 | 2% |
| Colombia | 1 | 2% |
| Switzerland | 1 | 2% |
| Estonia | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 9 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 25 | 56% |
| Members of the public | 19 | 42% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 205 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 4% |
| Germany | 1 | <1% |
| Sweden | 1 | <1% |
| Switzerland | 1 | <1% |
| Japan | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 192 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 58 | 28% |
| Researcher | 56 | 27% |
| Student > Master | 17 | 8% |
| Student > Bachelor | 15 | 7% |
| Student > Doctoral Student | 8 | 4% |
| Other | 29 | 14% |
| Unknown | 22 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 80 | 39% |
| Biochemistry, Genetics and Molecular Biology | 67 | 33% |
| Medicine and Dentistry | 12 | 6% |
| Computer Science | 5 | 2% |
| Immunology and Microbiology | 3 | 1% |
| Other | 11 | 5% |
| Unknown | 27 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 August 2023.
All research outputs
#1,268,446
of 25,373,627 outputs
Outputs from Genome Biology
#973
of 4,467 outputs
Outputs of similar age
#22,546
of 405,733 outputs
Outputs of similar age from Genome Biology
#17
of 62 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 405,733 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.