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Neuroprotection from NMDA excitotoxic lesion by Cu/Zn superoxide dismutase gene delivery to the postnatal rat brain by a modular protein vector

Overview of attention for article published in BMC Neuroscience, April 2006
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Mentioned by

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1 Google+ user

Citations

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31 Dimensions

Readers on

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28 Mendeley
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1 CiteULike
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Title
Neuroprotection from NMDA excitotoxic lesion by Cu/Zn superoxide dismutase gene delivery to the postnatal rat brain by a modular protein vector
Published in
BMC Neuroscience, April 2006
DOI 10.1186/1471-2202-7-35
Pubmed ID
Authors

Hugo Peluffo, Laia Acarin, Anna Arís, Pau González, Antoni Villaverde, Bernardo Castellano, Berta González

Abstract

Superoxide mediated oxidative stress is a key neuropathologic mechanism in acute central nervous system injuries. We have analyzed the neuroprotective efficacy of the transient overexpression of antioxidant enzyme Cu/Zn Superoxide dismutase (SOD) after excitotoxic injury to the immature rat brain by using a recently constructed modular protein vector for non-viral gene delivery termed NLSCt. For this purpose, animals were injected with the NLSCt vector carrying the Cu/Zn SOD or the control GFP transgenes 2 hours after intracortical N-methyl-D-aspartate (NMDA) administration, and daily functional evaluation was performed. Moreover, 3 days after, lesion volume, neuronal degeneration and nitrotyrosine immunoreactivity were evaluated.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 4%
Japan 1 4%
Spain 1 4%
United States 1 4%
Unknown 24 86%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 29%
Student > Master 7 25%
Professor 2 7%
Student > Postgraduate 2 7%
Student > Ph. D. Student 2 7%
Other 5 18%
Unknown 2 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 25%
Medicine and Dentistry 7 25%
Neuroscience 5 18%
Biochemistry, Genetics and Molecular Biology 3 11%
Psychology 1 4%
Other 2 7%
Unknown 3 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 December 2011.
All research outputs
#7,761,966
of 12,372,276 outputs
Outputs from BMC Neuroscience
#544
of 993 outputs
Outputs of similar age
#117,049
of 221,668 outputs
Outputs of similar age from BMC Neuroscience
#26
of 53 outputs
Altmetric has tracked 12,372,276 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 993 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 221,668 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.