Report for: Regulation of BRCA1 expression and its relationship to sporadic breast cancer

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Title	Regulation of BRCA1 expression and its relationship to sporadic breast cancer
Published in	Breast Cancer Research, December 2002
DOI	10.1186/bcr557
Pubmed ID	12559046
Authors	Christopher R Mueller, Calvin D Roskelley
Abstract	Germ-line mutations in the BRCA1 tumour suppressor gene contribute to familial breast tumour formation, but there is no evidence for direct mutation of the BRCA1 gene in the sporadic form of the disease. In contrast, decreased expression of the BRCA1 gene has been shown to be common in sporadic tumours, and the magnitude of the decrease correlates with disease progression. BRCA1 expression is also tightly regulated during normal breast development. Determining how these developmental regulators of BRCA1 expression are co-opted during breast tumourigenesis could lead to a better understanding of sporadic breast cancer aetiology and the generation of novel therapeutic strategies aimed at preventing sporadic breast tumour progression.

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Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
United States	1	1%
India	1	1%
Belgium	1	1%
Australia	1	1%
Unknown	79	95%

Demographic breakdown

Readers by professional status	Count	As %
Student > Ph. D. Student	19	23%
Researcher	19	23%
Student > Bachelor	15	18%
Student > Master	11	13%
Professor > Associate Professor	3	4%
Other	8	10%
Unknown	8	10%

Readers by discipline	Count	As %
Biochemistry, Genetics and Molecular Biology	34	41%
Agricultural and Biological Sciences	25	30%
Medicine and Dentistry	8	10%
Chemistry	3	4%
Immunology and Microbiology	1	1%
Other	3	4%
Unknown	9	11%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 July 2021.

All research outputs

#7,472,296

of 22,844,985 outputs

Outputs from Breast Cancer Research

#880

of 1,901 outputs

Outputs of similar age

#31,437

of 129,033 outputs

Outputs of similar age from Breast Cancer Research

of 9 outputs

Altmetric has tracked 22,844,985 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.

So far Altmetric has tracked 1,901 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.9. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.

Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 129,033 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.

We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.

Regulation of BRCA1 expression and its relationship to sporadic breast cancer

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Mendeley readers

Geographical breakdown

Demographic breakdown

Attention Score in Context