Title |
Regulation of BRCA1 expression and its relationship to sporadic breast cancer
|
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Published in |
Breast Cancer Research, December 2002
|
DOI | 10.1186/bcr557 |
Pubmed ID | |
Authors |
Christopher R Mueller, Calvin D Roskelley |
Abstract |
Germ-line mutations in the BRCA1 tumour suppressor gene contribute to familial breast tumour formation, but there is no evidence for direct mutation of the BRCA1 gene in the sporadic form of the disease. In contrast, decreased expression of the BRCA1 gene has been shown to be common in sporadic tumours, and the magnitude of the decrease correlates with disease progression. BRCA1 expression is also tightly regulated during normal breast development. Determining how these developmental regulators of BRCA1 expression are co-opted during breast tumourigenesis could lead to a better understanding of sporadic breast cancer aetiology and the generation of novel therapeutic strategies aimed at preventing sporadic breast tumour progression. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
India | 1 | 1% |
Belgium | 1 | 1% |
Australia | 1 | 1% |
Unknown | 79 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 19 | 23% |
Researcher | 19 | 23% |
Student > Bachelor | 15 | 18% |
Student > Master | 11 | 13% |
Professor > Associate Professor | 3 | 4% |
Other | 8 | 10% |
Unknown | 8 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 34 | 41% |
Agricultural and Biological Sciences | 25 | 30% |
Medicine and Dentistry | 8 | 10% |
Chemistry | 3 | 4% |
Immunology and Microbiology | 1 | 1% |
Other | 3 | 4% |
Unknown | 9 | 11% |