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In-hospital free fatty acids levels predict the severity of myocardial ischemia of acute coronary syndrome

Overview of attention for article published in BMC Cardiovascular Disorders, February 2016
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Title
In-hospital free fatty acids levels predict the severity of myocardial ischemia of acute coronary syndrome
Published in
BMC Cardiovascular Disorders, February 2016
DOI 10.1186/s12872-016-0199-1
Pubmed ID
Authors

Pei Ma, Lu Han, Zhihua Lv, Wei Chen, Hanning Hu, Jiancheng Tu, Xin Zhou, Song-Mei Liu

Abstract

We aimed to assess whether the levels of FFAs (free fatty acids) in ACS (acute coronary syndrome) patients depend on the extent of myocardial ischemia during the subacute phase of ACS attack. A total of 892 consecutive CAD (coronary artery disease) subjects undergoing coronary angiography were enrolled. The FFAs contents were measured based on enzymatic assay. The relationship between FFAs and Gensini score and ACS susceptibility was assessed. In the overall population, the upper FFAs quartile was accompanied with higher ischemia parameters and increased occurrence of ACS and STEMI (ST-segment elevation myocardial infarction) (P < 0.05). The FFAs concentrations were approximately 1.5-fold higher in ACS than in stable CAD patients, roughly 1.3-fold higher in STEMI than non-STEMI ACS patients and probably 1.3-fold higher in non-STEMI ACS than in stable CAD patients. After adjusted for traditional cardiovascular risk factors, the FFAs level remained a risk factor for a higher Gensini score with more than 40 (P < 0.001) and prevalent ACS (P < 0.001). After adjusted for traditional risk factors, FFAs levels after natural logarithm transformation were associated with hs-CRP and WBC counts in ACS patients. A multiplicative interaction was found between hs-CRP, WBC counts and FFAs in incident ACS and higher Gensini score (P < 0.001). Higher in-hospital levels of FFAs persist and may reflect the severity of ischemia and necrosis during the subacute phase of ACS attack.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 29%
Other 2 14%
Student > Doctoral Student 1 7%
Lecturer 1 7%
Student > Master 1 7%
Other 1 7%
Unknown 4 29%
Readers by discipline Count As %
Medicine and Dentistry 6 43%
Biochemistry, Genetics and Molecular Biology 1 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 7%
Computer Science 1 7%
Agricultural and Biological Sciences 1 7%
Other 0 0%
Unknown 4 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 February 2016.
All research outputs
#18,867,895
of 24,051,764 outputs
Outputs from BMC Cardiovascular Disorders
#1,149
of 1,768 outputs
Outputs of similar age
#279,103
of 405,276 outputs
Outputs of similar age from BMC Cardiovascular Disorders
#22
of 37 outputs
Altmetric has tracked 24,051,764 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,768 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 405,276 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.