Title |
Directly-observed therapy (DOT) for the radical 14-day primaquine treatment of Plasmodium vivax malaria on the Thai-Myanmar border
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Published in |
Malaria Journal, November 2010
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DOI | 10.1186/1475-2875-9-308 |
Pubmed ID | |
Authors |
Rie Takeuchi, Saranath Lawpoolsri, Mallika Imwong, Jun Kobayashi, Jaranit Kaewkungwal, Sasithon Pukrittayakamee, Supalap Puangsa-art, Nipon Thanyavanich, Wanchai Maneeboonyang, Nicholas PJ Day, Pratap Singhasivanon |
Abstract |
Plasmodium vivax has a dormant hepatic stage, called the hypnozoite, which can cause relapse months after the initial attack. For 50 years, primaquine has been used as a hypnozoitocide to radically cure P. vivax infection, but major concerns remain regarding the side-effects of the drug and adherence to the 14-day regimen. This study examined the effectiveness of using the directly-observed therapy (DOT) method for the radical treatment of P. vivax malaria infection, to prevent reappearance of the parasite within the 90-day follow-up period. Other potential risk factors for the reappearance of P. vivax were also explored. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 2% |
Australia | 1 | <1% |
Pakistan | 1 | <1% |
South Africa | 1 | <1% |
Philippines | 1 | <1% |
Unknown | 112 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 17 | 14% |
Student > Ph. D. Student | 15 | 13% |
Student > Master | 15 | 13% |
Other | 10 | 8% |
Student > Bachelor | 8 | 7% |
Other | 25 | 21% |
Unknown | 28 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 38 | 32% |
Agricultural and Biological Sciences | 18 | 15% |
Biochemistry, Genetics and Molecular Biology | 6 | 5% |
Social Sciences | 6 | 5% |
Nursing and Health Professions | 4 | 3% |
Other | 17 | 14% |
Unknown | 29 | 25% |