Title |
Simultaneous gene expression profiling in human macrophages infected with Leishmania major parasites using SAGE
|
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Published in |
BMC Genomics, May 2008
|
DOI | 10.1186/1471-2164-9-238 |
Pubmed ID | |
Authors |
Fatma Z Guerfali, Dhafer Laouini, Lamia Guizani-Tabbane, Florence Ottones, Khadija Ben-Aissa, Alia Benkahla, Laurent Manchon, David Piquemal, Sondos Smandi, Ons Mghirbi, Thérèse Commes, Jacques Marti, Koussay Dellagi |
Abstract |
Leishmania (L) are intracellular protozoan parasites that are able to survive and replicate within the harsh and potentially hostile phagolysosomal environment of mammalian mononuclear phagocytes. A complex interplay then takes place between the macrophage (MPhi) striving to eliminate the pathogen and the parasite struggling for its own survival. To investigate this host-parasite conflict at the transcriptional level, in the context of monocyte-derived human MPhis (MDM) infection by L. major metacyclic promastigotes, the quantitative technique of serial analysis of gene expression (SAGE) was used. |
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Geographical breakdown
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United States | 5 | 5% |
Brazil | 2 | 2% |
United Kingdom | 1 | <1% |
Germany | 1 | <1% |
Belgium | 1 | <1% |
Tunisia | 1 | <1% |
Unknown | 94 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 26 | 25% |
Researcher | 19 | 18% |
Professor > Associate Professor | 10 | 10% |
Student > Master | 10 | 10% |
Student > Bachelor | 7 | 7% |
Other | 15 | 14% |
Unknown | 18 | 17% |
Readers by discipline | Count | As % |
---|---|---|
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Immunology and Microbiology | 16 | 15% |
Biochemistry, Genetics and Molecular Biology | 13 | 12% |
Engineering | 4 | 4% |
Medicine and Dentistry | 3 | 3% |
Other | 3 | 3% |
Unknown | 19 | 18% |