Title |
Evolution of two distinct phylogenetic lineages of the emerging human pathogen Mycobacterium ulcerans
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Published in |
BMC Ecology and Evolution, September 2007
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DOI | 10.1186/1471-2148-7-177 |
Pubmed ID | |
Authors |
Michael Käser, Simona Rondini, Martin Naegeli, Tim Stinear, Francoise Portaels, Ulrich Certa, Gerd Pluschke |
Abstract |
Comparative genomics has greatly improved our understanding of the evolution of pathogenic mycobacteria such as Mycobacterium tuberculosis. Here we have used data from a genome microarray analysis to explore insertion-deletion (InDel) polymorphism among a diverse strain collection of Mycobacterium ulcerans, the causative agent of the devastating skin disease, Buruli ulcer. Detailed analysis of large sequence polymorphisms in twelve regions of difference (RDs), comprising irreversible genetic markers, enabled us to refine the phylogenetic succession within M. ulcerans, to define features of a hypothetical M. ulcerans most recent common ancestor and to confirm its origin from Mycobacterium marinum. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 1% |
United States | 1 | 1% |
Belgium | 1 | 1% |
Unknown | 70 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 17 | 23% |
Researcher | 14 | 19% |
Student > Bachelor | 9 | 12% |
Student > Master | 6 | 8% |
Student > Doctoral Student | 5 | 7% |
Other | 11 | 15% |
Unknown | 11 | 15% |
Readers by discipline | Count | As % |
---|---|---|
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Biochemistry, Genetics and Molecular Biology | 12 | 16% |
Medicine and Dentistry | 11 | 15% |
Immunology and Microbiology | 5 | 7% |
Chemistry | 3 | 4% |
Other | 5 | 7% |
Unknown | 15 | 21% |