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Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II-induced arthritis

Overview of attention for article published in Arthritis Research & Therapy, January 2008
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Citations

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56 Mendeley
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Title
Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II-induced arthritis
Published in
Arthritis Research & Therapy, January 2008
DOI 10.1186/ar2347
Pubmed ID
Authors

Therese Östberg, Heidi Wähämaa, Karin Palmblad, Norimasa Ito, Pernilla Stridh, Maria Shoshan, Michael T Lotze, Helena Erlandsson Harris, Ulf Andersson

Abstract

High mobility group box chromosomal protein 1 (HMGB1) is a nuclear protein that acts as a pro-inflammatory mediator following extracellular release. The protein is aberrantly expressed extracellularly in the settings of clinical and experimental synovitis. Therapy based on HMGB1 antagonists has shown encouraging results in experimental arthritis and warrants further scientific exploration using independent methods. In the present study we asked whether nuclear sequestration of HMGB1 preventing HMGB1 release would be beneficial for synovitis treatment.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
United States 1 2%
Italy 1 2%
Unknown 53 95%

Demographic breakdown

Readers by professional status Count As %
Professor 4 7%
Student > Master 4 7%
Professor > Associate Professor 4 7%
Student > Doctoral Student 3 5%
Student > Ph. D. Student 3 5%
Other 5 9%
Unknown 33 59%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 16%
Medicine and Dentistry 5 9%
Biochemistry, Genetics and Molecular Biology 3 5%
Immunology and Microbiology 3 5%
Social Sciences 1 2%
Other 1 2%
Unknown 34 61%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2008.
All research outputs
#17,285,668
of 25,373,627 outputs
Outputs from Arthritis Research & Therapy
#2,536
of 3,381 outputs
Outputs of similar age
#143,780
of 168,813 outputs
Outputs of similar age from Arthritis Research & Therapy
#14
of 16 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 168,813 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.