Title |
Impaired learning and memory in CD38 null mutant mice
|
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Published in |
Molecular Brain, February 2016
|
DOI | 10.1186/s13041-016-0195-5 |
Pubmed ID | |
Authors |
Somi Kim, TaeHyun Kim, Hye-Ryeon Lee, Eun-Hye Jang, Hyun-Hee Ryu, Minkyung Kang, So-Young Rah, Juyoun Yoo, Bolam Lee, Jae-Ick Kim, Chae Seok Lim, Sang Jeong Kim, Uh-Hyun Kim, Yong-Seok Lee, Bong-Kiun Kaang |
Abstract |
CD38 is an enzyme that catalyzes the formation of cyclic ADP ribose and nicotinic acid adenine dinucleotide phosphate, both of which are involved in the mobilization of Ca(2+) from intracellular stores. Recently, CD38 has been shown to regulate oxytocin release from hypothalamic neurons. Importantly, CD38 mutations are associated with autism spectrum disorders (ASD) and CD38 knockout (CD38(-/-)) mice display ASD-like behavioral phenotypes including deficient parental behavior and poor social recognition memory. Although ASD and learning deficits commonly co-occur, the role of CD38 in learning and memory has not been investigated. We report that CD38(-/-) mice show deficits in various learning and memory tasks such as the Morris water maze, contextual fear conditioning, and the object recognition test. However, either long-term potentiation or long-term depression is not impaired in the hippocampus of CD38(-/-) mice. Our results provide convincing evidence that CD38(-/-) mice show deficits in various learning and memory tasks including spatial and non-spatial memory tasks. Our data demonstrate that CD38 is critical for regulating hippocampus-dependent learning and memory without modulating synaptic plasticity. |
X Demographics
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Brazil | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
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Scientists | 1 | 25% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
Geographical breakdown
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Unknown | 61 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 13 | 21% |
Researcher | 9 | 15% |
Student > Bachelor | 8 | 13% |
Student > Master | 6 | 10% |
Student > Doctoral Student | 3 | 5% |
Other | 9 | 15% |
Unknown | 13 | 21% |
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Agricultural and Biological Sciences | 9 | 15% |
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Immunology and Microbiology | 3 | 5% |
Other | 7 | 11% |
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