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Diagnostic role of inflammatory markers in pediatric Brucella arthritis

Overview of attention for article published in Italian Journal of Pediatrics, January 2016
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Title
Diagnostic role of inflammatory markers in pediatric Brucella arthritis
Published in
Italian Journal of Pediatrics, January 2016
DOI 10.1186/s13052-016-0211-5
Pubmed ID
Authors

Aktar, Fesih, Tekin, Recep, Bektaş, Mehmet Selçuk, Güneş, Ali, Köşker, Muhammet, Ertuğrul, Sabahattin, Yılmaz, Kamil, Karaman, Kamuran, Balık, Hasan, Yolbaş, İlyas

Abstract

As a multisystem infectious disease, there is an inflammation, which causes increase in acute phase reactants in brucellosis. The mean platelet volume (MPV), platelet distribution width (PDW), red cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have been identified as markers of inflammation. The present study aimed to evaluate diagnostic values of these biomarkers in brucella arthritis (BA). The study included 64 children with BA and 66 healthy control subjects. Demographic features, joint involvement, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and hematological variables were retrospectively recorded. In addition, results of synovial fluid and serum tube agglutination test for brucella together with treatment regimens were recorded. The mean age of the patients (53.1 % male) was 92.3 ± 41.2 months. The most commonly affected joint was ankle (53.1 %). Synovial fluid puncture-brucella agglutination test was positive in 22 (34.3 %) patients. Puncture culture was positive in 9 patients. Most of the patients (57.8 %) were treated with a combination of rifampicin plus sulfamethoxazole/trimethoprim and gentamicin. Significantly higher mean PDW, RDW, MPV, NLR and PLR values were found in children with BA compared to control subjects (p < 0.05). A positive correlation was found between MPV and NLR values (R (2) = 0.192, p < 0.001). Our findings indicated that NLR and PLR are indirect markers of inflammation that may be observed abnormally increased in children with brucella arthritis. Further longitudinal studies are needed to investigate this topic to establish the more clear associations.

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Twitter Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Singapore 1 3%
Unknown 29 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 27%
Other 4 13%
Student > Doctoral Student 4 13%
Student > Ph. D. Student 3 10%
Student > Bachelor 2 7%
Other 6 20%
Unknown 3 10%
Readers by discipline Count As %
Medicine and Dentistry 13 43%
Unspecified 2 7%
Nursing and Health Professions 2 7%
Immunology and Microbiology 2 7%
Agricultural and Biological Sciences 2 7%
Other 4 13%
Unknown 5 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2016.
All research outputs
#20,305,223
of 22,844,985 outputs
Outputs from Italian Journal of Pediatrics
#761
of 940 outputs
Outputs of similar age
#330,615
of 393,571 outputs
Outputs of similar age from Italian Journal of Pediatrics
#19
of 26 outputs
Altmetric has tracked 22,844,985 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.