Title |
Children with recurrent pneumonia and non-cystic fibrosis bronchiectasis
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Published in |
Italian Journal of Pediatrics, February 2016
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DOI | 10.1186/s13052-016-0225-z |
Pubmed ID | |
Authors |
Maria Francesca Patria, Benedetta Longhi, Mara Lelii, Claudia Tagliabue, Marinella Lavelli, Carlotta Galeone, Nicola Principi, Susanna Esposito |
Abstract |
Recurrent pneumonia (RP) is one of the most frequent causes of pediatric non-cystic fibrosis (CF) bronchiectasis (BE) and a consequent accelerated decline in lung function. The aim of this study was to analyse the clinical records of children with RP in attempt to identify factors that may lead to an early suspicion of non-CF BE. We recorded the demographic and clinical data, and lung function test results of children without CF attending our outpatient RP clinic between January 2009 to December 2013 who had undergone chest high-resolution computed tomography ≥8 weeks after an acute pneumonia episode and ≤6 months before enrolment. The study involved 42 patients with RP: 21 with and 21 without non-CF BE. The most frequent underlying diseases in both groups were chronic rhinosinusitis with post-nasal drip and recurrent wheezing (81 % and 71.4 % of those with, and 85.7 % and 71.4 % of those without BE). FEV1 and FEF25-75 values were significantly lower in the children with non-CF BE than in those without (77.9 ± 17.8 vs 96.8 ± 12.4, p = 0.004; 69.3 ± 25.6 vs 89.3 ± 21.9, p = 0.048). Bronchodilator responsiveness was observed in seven children with BE (33.3 %) and two without (9.5 %; p = 0.13). Reduced FEV1 and FEF25-75 values seem associated with an increased risk of developing non-CF BE in children with RP. This suggests a need for further studies to confirm the diagnostic usefulness use of spirometry in such cases. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 47 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 8 | 17% |
Student > Master | 6 | 13% |
Researcher | 5 | 11% |
Student > Postgraduate | 5 | 11% |
Student > Doctoral Student | 2 | 4% |
Other | 10 | 21% |
Unknown | 11 | 23% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 17 | 36% |
Biochemistry, Genetics and Molecular Biology | 3 | 6% |
Nursing and Health Professions | 3 | 6% |
Agricultural and Biological Sciences | 2 | 4% |
Immunology and Microbiology | 2 | 4% |
Other | 5 | 11% |
Unknown | 15 | 32% |