Title |
Multiple origins of resistance-conferring mutations in Plasmodium vivax dihydrofolate reductase
|
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Published in |
Malaria Journal, April 2008
|
DOI | 10.1186/1475-2875-7-72 |
Pubmed ID | |
Authors |
Vivian N Hawkins, Alyson Auliff, Surendra Kumar Prajapati, Kanchana Rungsihirunrat, Hapuarachchige C Hapuarachchi, Amanda Maestre, Michael T O'Neil, Qin Cheng, Hema Joshi, Kesara Na-Bangchang, Carol Hopkins Sibley |
Abstract |
In order to maximize the useful therapeutic life of antimalarial drugs, it is crucial to understand the mechanisms by which parasites resistant to antimalarial drugs are selected and spread in natural populations. Recent work has demonstrated that pyrimethamine-resistance conferring mutations in Plasmodium falciparum dihydrofolate reductase (dhfr) have arisen rarely de novo, but spread widely in Asia and Africa. The origin and spread of mutations in Plasmodium vivax dhfr were assessed by constructing haplotypes based on sequencing dhfr and its flanking regions. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 2% |
United Kingdom | 1 | 2% |
Unknown | 54 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 21% |
Student > Master | 10 | 18% |
Student > Ph. D. Student | 8 | 14% |
Student > Bachelor | 4 | 7% |
Other | 3 | 5% |
Other | 7 | 13% |
Unknown | 12 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 30% |
Biochemistry, Genetics and Molecular Biology | 9 | 16% |
Agricultural and Biological Sciences | 8 | 14% |
Social Sciences | 3 | 5% |
Immunology and Microbiology | 3 | 5% |
Other | 4 | 7% |
Unknown | 12 | 21% |