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Mendeley readers
Title |
Insights into integrin-ligand binding and activation from the first crystal structure
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Published in |
Arthritis Research & Therapy, May 2002
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DOI | 10.1186/ar563 |
Pubmed ID | |
Authors |
Martin J Humphries |
Abstract |
Integrin receptors transduce bidirectional signals between extracellular adhesion molecules and intracellular cytoskeletal and signalling molecules. The structural basis of integrin signalling is unknown, but the recent publication of the first crystal structure of the extracellular domain of integrin alphaVbeta3 has provided a number of insights. In this review, previous structure-function analyses of integrins that have employed biochemical and molecular biological approaches are placed in the context of the crystal structure, and novel routes to the development of integrin antagonists are discussed. |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 5% |
United Kingdom | 1 | 3% |
Switzerland | 1 | 3% |
Unknown | 33 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 15 | 41% |
Researcher | 8 | 22% |
Student > Bachelor | 3 | 8% |
Student > Doctoral Student | 2 | 5% |
Professor > Associate Professor | 2 | 5% |
Other | 7 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 18 | 49% |
Biochemistry, Genetics and Molecular Biology | 6 | 16% |
Medicine and Dentistry | 5 | 14% |
Chemistry | 4 | 11% |
Unspecified | 1 | 3% |
Other | 1 | 3% |
Unknown | 2 | 5% |