@EvolvedBiofilm @SmitsLab @nanopore @illumina Assembling the long reads first and polishing with the short reads appeared to result in more contiguous assemblies, which is also the conclusion of this paper by Goldstein et al. (https://t.co/y57hBg9BS4)
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@surt_lab If there is bias in your short read library (e.g., missing high GC regions) then your long reads can't help because long read info isn't added to the graph, they are only to help its resolution. You might be interested in https://t.co/v58AgEYT2
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RT @MColebrook: Evaluation of strategies for the assembly of diverse #bacterial #genomes using #MinION long-read sequencing https://t.co/Ke…
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RT @MColebrook: Evaluation of strategies for the assembly of diverse #bacterial #genomes using #MinION long-read sequencing https://t.co/Ke…