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A phase 2 randomized, double-blind study of AMG 108, a fully human monoclonal antibody to IL-1R, in patients with rheumatoid arthritis

Overview of attention for article published in Arthritis Research & Therapy, October 2010
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Title
A phase 2 randomized, double-blind study of AMG 108, a fully human monoclonal antibody to IL-1R, in patients with rheumatoid arthritis
Published in
Arthritis Research & Therapy, October 2010
DOI 10.1186/ar3163
Pubmed ID
Authors

Mario H Cardiel, Paul P Tak, William Bensen, Francis X Burch, Sarka Forejtova, Janusz E Badurski, Tarundeep Kakkar, Terry Bevirt, Liyun Ni, Ellen McCroskery, Angelika Jahreis, Debra J Zack

Abstract

Preclinical work has suggested that IL-1 plays a critical role in the pathogenesis of rheumatoid arthritis (RA). The objective of the present study was to determine the effect of a long-acting IL-1 receptor inhibitor, AMG 108, in a double-blind, placebo-controlled, parallel-dosing study in patients with active RA who were receiving stable methotrexate (15 to 25 mg/week).

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 2 4%
United Kingdom 1 2%
United States 1 2%
Norway 1 2%
Unknown 51 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 20%
Other 7 13%
Researcher 7 13%
Student > Postgraduate 6 11%
Student > Bachelor 4 7%
Other 9 16%
Unknown 12 21%
Readers by discipline Count As %
Medicine and Dentistry 24 43%
Pharmacology, Toxicology and Pharmaceutical Science 4 7%
Agricultural and Biological Sciences 4 7%
Immunology and Microbiology 2 4%
Engineering 2 4%
Other 5 9%
Unknown 15 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2011.
All research outputs
#17,286,645
of 25,374,917 outputs
Outputs from Arthritis Research & Therapy
#2,536
of 3,380 outputs
Outputs of similar age
#88,026
of 108,180 outputs
Outputs of similar age from Arthritis Research & Therapy
#22
of 25 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,380 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 108,180 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.