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The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers

Overview of attention for article published in BMC Medical Genomics, December 2011
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Title
The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers
Published in
BMC Medical Genomics, December 2011
DOI 10.1186/1471-2350-12-173
Pubmed ID
Authors

Asif S Tulah, Stuart G Parker, Miriam F Moffatt, Andrew J Wardlaw, Martin J Connolly, Ian Sayers

Abstract

We have previously shown evidence that polymorphisms within genes controlling leukotriene B4 (LTB4) production (ALOX5AP and LTA4H) are associated with asthma susceptibility in children. Evidence also suggests a potential role of LTB4 in COPD disease mechanisms including recruitment of neutrophils to the lung. The aim of the current study was to see if these SNPs and those spanning the receptor genes for LTB4 (LTB4R1 and LTB4R2) influence baseline lung function and COPD susceptibility/severity in smokers.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 20%
Student > Ph. D. Student 5 17%
Student > Postgraduate 4 13%
Professor 3 10%
Student > Bachelor 2 7%
Other 3 10%
Unknown 7 23%
Readers by discipline Count As %
Medicine and Dentistry 11 37%
Pharmacology, Toxicology and Pharmaceutical Science 3 10%
Nursing and Health Professions 3 10%
Agricultural and Biological Sciences 2 7%
Biochemistry, Genetics and Molecular Biology 1 3%
Other 2 7%
Unknown 8 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 December 2011.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from BMC Medical Genomics
#2,010
of 2,444 outputs
Outputs of similar age
#228,035
of 249,550 outputs
Outputs of similar age from BMC Medical Genomics
#31
of 34 outputs
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We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.