Title |
Molecular profiling of breast cancer: portraits but not physiognomy
|
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Published in |
Breast Cancer Research, December 2000
|
DOI | 10.1186/bcr274 |
Pubmed ID | |
Authors |
James D Brenton, Samuel AJR Aparicio, Carlos Caldas |
Abstract |
Breast cancers differ in response to treatment and may have a divergent clinical course despite having a similar histopathological appearance. New technology using DNA microarrays provides a systematic method to identify key markers for prognosis and treatment response by profiling thousands of genes expressed in a single cancer. Microarray profiling of 38 invasive breast cancers now confirms striking molecular differences between ductal carcinoma specimens and suggests a new classification for oestrogen-receptor negative breast cancer. Future approaches will need to include methods for high-throughput clinical validation and the ability to analyze microscopic samples. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 4% |
United Kingdom | 1 | 4% |
Canada | 1 | 4% |
China | 1 | 4% |
United States | 1 | 4% |
Unknown | 22 | 81% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 22% |
Professor > Associate Professor | 5 | 19% |
Researcher | 3 | 11% |
Student > Bachelor | 2 | 7% |
Student > Postgraduate | 2 | 7% |
Other | 5 | 19% |
Unknown | 4 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 9 | 33% |
Medicine and Dentistry | 6 | 22% |
Biochemistry, Genetics and Molecular Biology | 4 | 15% |
Unspecified | 1 | 4% |
Immunology and Microbiology | 1 | 4% |
Other | 1 | 4% |
Unknown | 5 | 19% |