Title |
Pro-inflammatory gene expression in solid glioblastoma microenvironment and in hypoxic stem cells from human glioblastoma
|
---|---|
Published in |
Journal of Neuroinflammation, April 2011
|
DOI | 10.1186/1742-2094-8-32 |
Pubmed ID | |
Authors |
Marco Tafani, Maura Di Vito, Alessandro Frati, Laura Pellegrini, Elena De Santis, Giovanni Sette, Adriana Eramo, Patrizio Sale, Emanuela Mari, Antonio Santoro, Antonino Raco, Maurizio Salvati, Ruggero De Maria, Matteo A Russo |
Abstract |
Adaptation to hypoxia and consequent pro-inflammatory gene expression of prostate and breast carcinomas have been implicated in the progression toward cancer malignant phenotype. Only partial data are available for the human tumor glioblastoma multiforme (GBM). The aim of our study was to analyze the hypoxic and pro-inflammatory microenvironment in GBMs and to demonstrate that in a stem/progenitor cell line derived from human glioblastoma (GBM-SCs), hypoxia activates a coordinated inflammatory response, evidencing an invasive and migratory phenotype. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 3% |
Sweden | 1 | <1% |
Italy | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 109 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 27 | 23% |
Researcher | 18 | 16% |
Student > Bachelor | 13 | 11% |
Student > Master | 13 | 11% |
Unspecified | 7 | 6% |
Other | 22 | 19% |
Unknown | 15 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 25 | 22% |
Agricultural and Biological Sciences | 22 | 19% |
Biochemistry, Genetics and Molecular Biology | 20 | 17% |
Unspecified | 7 | 6% |
Neuroscience | 6 | 5% |
Other | 14 | 12% |
Unknown | 21 | 18% |