Title |
Matrix metalloproteinases in arthritic disease
|
---|---|
Published in |
Arthritis Research & Therapy, May 2002
|
DOI | 10.1186/ar572 |
Pubmed ID | |
Authors |
Gillian Murphy, Vera Knäuper, Susan Atkinson, George Butler, William English, Mike Hutton, Jan Stracke, Ian Clark |
Abstract |
The role of matrix metalloproteinases in the degradative events invoked in the cartilage and bone of arthritic joints has long been appreciated and attempts at the development of proteinase inhibitors as potential therapeutic agents have been made. However, the spectrum of these enzymes orchestrating connective tissue turnover and general biology is much larger than anticipated. Biochemical studies of the individual members of the matrix metalloproteinase family are now underway, ultimately leading to a more detailed understanding of the function of their domain structures and to defining their specific role in cellular systems and the way that they are regulated. Coupled with a more comprehensive and detailed study of proteinase expression in different cells of joint tissues during the progress of arthritic diseases, it will be possible for the future development and application of highly specific proteinase inhibitors to be directed at specific key cellular events. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Germany | 1 | <1% |
Unknown | 127 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 26 | 20% |
Student > Ph. D. Student | 20 | 16% |
Student > Master | 20 | 16% |
Student > Bachelor | 17 | 13% |
Lecturer > Senior Lecturer | 5 | 4% |
Other | 20 | 16% |
Unknown | 21 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 28 | 22% |
Biochemistry, Genetics and Molecular Biology | 27 | 21% |
Agricultural and Biological Sciences | 22 | 17% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 5% |
Chemistry | 6 | 5% |
Other | 15 | 12% |
Unknown | 24 | 19% |