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Regulatory T cells and control of the germinal centre response

Overview of attention for article published in Arthritis Research & Therapy, October 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)

Mentioned by

news
1 news outlet

Citations

dimensions_citation
31 Dimensions

Readers on

mendeley
73 Mendeley
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Title
Regulatory T cells and control of the germinal centre response
Published in
Arthritis Research & Therapy, October 2014
DOI 10.1186/s13075-014-0471-7
Pubmed ID
Authors

Ine Vanderleyden, Michelle A Linterman, Kenneth GC Smith

Abstract

Germinal centres (GCs) are specialised lymphoid microenvironments that form in secondary B-cell follicles upon exposure to T-dependent antigens. In the GC, clonal expansion, selection and differentiation of GC B cells result in the production of high-affinity plasma cells and memory B cells that provide protection against subsequent infection. The GC is carefully regulated to fulfil its critical role in defence against infection and to ensure that immunological tolerance is not broken in the process. The GC response can be controlled by a number of mechanisms, one of which is by forkhead box p3 expressing regulatory T (Treg) cells, a suppressive population of CD4+ T cells. A specialised subset of Treg cells - follicular regulatory T (Tfr) cells - form after immunisation and are able to access the GC, where they control the size and output of the response. Our knowledge of Treg cell control of the GC is expanding. In this review we will discuss recent advances in the field, with a particular emphasis on the differentiation and function of Tfr cells in the GC.

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 1%
Peru 1 1%
Unknown 71 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 21%
Student > Bachelor 14 19%
Researcher 13 18%
Student > Master 6 8%
Student > Postgraduate 4 5%
Other 9 12%
Unknown 12 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 25%
Immunology and Microbiology 13 18%
Medicine and Dentistry 12 16%
Biochemistry, Genetics and Molecular Biology 12 16%
Environmental Science 1 1%
Other 3 4%
Unknown 14 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 June 2019.
All research outputs
#2,589,155
of 15,175,259 outputs
Outputs from Arthritis Research & Therapy
#649
of 2,386 outputs
Outputs of similar age
#64,012
of 343,173 outputs
Outputs of similar age from Arthritis Research & Therapy
#1
of 1 outputs
Altmetric has tracked 15,175,259 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,386 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,173 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them