Title |
Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer
|
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Published in |
BMC Genomics, April 2006
|
DOI | 10.1186/1471-2164-7-68 |
Pubmed ID | |
Authors |
Yaguang Xi, Go Nakajima, John C Schmitz, Edward Chu, Jingfang Ju |
Abstract |
Thymidylate synthase (TS) is a critical target for cancer chemotherapy and is one of the most extensively studied biomarkers for fluoropyrimidine-based chemotherapy. In addition to its critical role in enzyme catalysis, TS functions as an RNA binding protein to regulate the expression of its own mRNA translation and other cellular mRNAs, such as p53, at the translational level. In this study, a comprehensive gene expression analysis at the levels of both transcriptional and post-transcriptional regulation was conducted to identify response markers using human genome array with TS-depleted human colon cancer HCT-C18 (TS-) cells and HCT-C18 (TS+) cells stably transfected with the human TS cDNA expression plasmid. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 23 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 26% |
Researcher | 5 | 22% |
Student > Master | 2 | 9% |
Student > Bachelor | 2 | 9% |
Professor > Associate Professor | 2 | 9% |
Other | 2 | 9% |
Unknown | 4 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 43% |
Biochemistry, Genetics and Molecular Biology | 2 | 9% |
Medicine and Dentistry | 2 | 9% |
Social Sciences | 1 | 4% |
Chemistry | 1 | 4% |
Other | 0 | 0% |
Unknown | 7 | 30% |