Title |
Assessment of severe malaria in a multicenter, phase III, RTS, S/AS01 malaria candidate vaccine trial: case definition, standardization of data collection and patient care
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Published in |
Malaria Journal, August 2011
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DOI | 10.1186/1475-2875-10-221 |
Pubmed ID | |
Authors |
Johan Vekemans, Kevin Marsh, Brian Greenwood, Amanda Leach, William Kabore, Solange Soulanoudjingar, Kwaku Poku Asante, Daniel Ansong, Jennifer Evans, Jahit Sacarlal, Philip Bejon, Portia Kamthunzi, Nahya Salim, Patricia Njuguna, Mary J Hamel, Walter Otieno, Samwel Gesase, David Schellenberg, the Clinical Trials Partnership Committee |
Abstract |
An effective malaria vaccine, deployed in conjunction with other malaria interventions, is likely to substantially reduce the malaria burden. Efficacy against severe malaria will be a key driver for decisions on implementation. An initial study of an RTS, S vaccine candidate showed promising efficacy against severe malaria in children in Mozambique. Further evidence of its protective efficacy will be gained in a pivotal, multi-centre, phase III study. This paper describes the case definitions of severe malaria used in this study and the programme for standardized assessment of severe malaria according to the case definition. |
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Geographical breakdown
Country | Count | As % |
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United Kingdom | 4 | 3% |
Indonesia | 1 | <1% |
India | 1 | <1% |
Pakistan | 1 | <1% |
Unknown | 120 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 20 | 16% |
Researcher | 19 | 15% |
Student > Bachelor | 15 | 12% |
Student > Ph. D. Student | 13 | 10% |
Student > Postgraduate | 12 | 9% |
Other | 24 | 19% |
Unknown | 24 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 35 | 28% |
Agricultural and Biological Sciences | 21 | 17% |
Social Sciences | 12 | 9% |
Immunology and Microbiology | 7 | 6% |
Nursing and Health Professions | 5 | 4% |
Other | 22 | 17% |
Unknown | 25 | 20% |