Title |
Identification of a novel truncating PALB2mutation and analysis of its contribution to early-onset breast cancer in French-Canadian women
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Published in |
Breast Cancer Research, December 2007
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DOI | 10.1186/bcr1828 |
Pubmed ID | |
Authors |
William D Foulkes, Parviz Ghadirian, Mohammed Reza Akbari, Nancy Hamel, Sylvie Giroux, Nelly Sabbaghian, Andrew Darnel, Robert Royer, Aletta Poll, Eve Fafard, André Robidoux, Ginette Martin, Tarek A Bismar, Marc Tischkowitz, Francois Rousseau, Steven A Narod |
Abstract |
PALB2 has recently been identified as a breast cancer susceptibility gene. PALB2 mutations are rare causes of hereditary breast cancer but may be important in countries such as Finland where a founder mutation is present. We sought to estimate the contribution of PALB2 mutations to the burden of breast cancer in French Canadians from Quebec. We screened all coding exons of PALB2 in a sample of 50 French-Canadian women diagnosed with either early-onset breast cancer or familial breast cancer at a single Montreal hospital. The genetic variants identified in this sample were then studied in 356 additional women with breast cancer diagnosed before age 50 and in 6,448 newborn controls. We identified a single protein-truncating mutation in PALB2 (c.2323 C>T, resulting in Q775X) in 1 of the 50 high-risk women. This variant was present in 2 of 356 breast cancer cases and in none of 6,440 newborn French-Canadian controls (P = 0.003). We also identified two novel new non-synonymous single nucleotide polymorphisms in exon 4 of PALB2 (c.5038 A>G [I76V] and c.5156 G>T [G115V]). G115V was found in 1 of 356 cases and in 15 of 6,442 controls (P = 0.6). The I76V variant was not identified in either the extended case series or the controls. We have identified a novel truncating mutation in PALB2. The mutation was found in approximately 0.5% of unselected French-Canadian women with early-onset breast cancer and appears to have a single origin. Although mutations are infrequent, PALB2 can be added to the list of breast cancer susceptibility genes for which founder mutations have been identified in the French-Canadian population. |
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Geographical breakdown
Country | Count | As % |
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Canada | 1 | 2% |
Unknown | 60 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 12 | 19% |
Student > Ph. D. Student | 11 | 18% |
Student > Master | 8 | 13% |
Other | 7 | 11% |
Student > Bachelor | 6 | 10% |
Other | 9 | 15% |
Unknown | 9 | 15% |
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Mathematics | 1 | 2% |
Business, Management and Accounting | 1 | 2% |
Other | 7 | 11% |
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