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In vitro and in vivo double-enhanced suicide gene therapy mediated by generation 5 polyamidoamine dendrimers for PC-3 cell line

Overview of attention for article published in World Journal of Surgical Oncology, January 2012
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  • High Attention Score compared to outputs of the same age and source (87th percentile)

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29 Mendeley
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Title
In vitro and in vivo double-enhanced suicide gene therapy mediated by generation 5 polyamidoamine dendrimers for PC-3 cell line
Published in
World Journal of Surgical Oncology, January 2012
DOI 10.1186/1477-7819-10-3
Pubmed ID
Authors

Yue Chen, Gang Wang, Deling Kong, Zhihong Zhang, Kuo Yang, Ranlu Liu, Weiming Zhao, Yong Xu

Abstract

One of the most frequently used and efficient suicide gene therapies for prostate cancer is HSV-TK/GCV system, but its application has been limited due to lack of favorable gene vector and the reduction of "bystander effect". We investigated the effect of a novel combination of HSV-TK/GCV fused with Cx43 and gemcitabine using non-viral vector generation 5 polyamidoamine dendrimers (G5-PAMAM-D) on PC-3 cells.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 1 3%
Unknown 28 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 17%
Student > Ph. D. Student 4 14%
Student > Bachelor 3 10%
Student > Doctoral Student 3 10%
Professor 2 7%
Other 5 17%
Unknown 7 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 21%
Medicine and Dentistry 5 17%
Biochemistry, Genetics and Molecular Biology 2 7%
Computer Science 2 7%
Psychology 1 3%
Other 3 10%
Unknown 10 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 January 2012.
All research outputs
#13,127,753
of 22,661,413 outputs
Outputs from World Journal of Surgical Oncology
#344
of 2,038 outputs
Outputs of similar age
#143,235
of 242,109 outputs
Outputs of similar age from World Journal of Surgical Oncology
#8
of 64 outputs
Altmetric has tracked 22,661,413 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,038 research outputs from this source. They receive a mean Attention Score of 2.0. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,109 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.