Title |
A systematic review of the safety information contained within the Summaries of Product Characteristics of medications licensed in the United Kingdom for Attention Deficit Hyperactivity Disorder. how does the safety prescribing advice compare with national guidance?
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Published in |
Child and Adolescent Psychiatry and Mental Health, January 2012
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DOI | 10.1186/1753-2000-6-2 |
Pubmed ID | |
Authors |
Nicola Savill, Chris J Bushe |
Abstract |
The safety of paediatric medications is paramount and contraindications provide clear pragmatic advice. Further advice may be accessed through Summaries of Product Characteristics (SPCs) and relevant national guidelines. The SPC can be considered the ultimate independent guideline and is regularly updated. In 2008, the authors undertook a systematic review of the SPC contraindications of medications licensed in the United Kingdom (UK) for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). At that time, there were fewer contraindications reported in the SPC for atomoxetine than methylphenidate and the specific contraindications varied considerably amongst methylphenidate formulations. In 2009, the European Medicines Agency (EMA) mandated harmonisation of methylphenidate SPCs. Between September and November 2011, there were three changes to the atomoxetine SPC that resulted in revised prescribing information. In addition, Clinical Guidance has also been produced by the National Institute for Health and Clinical Excellence (NICE) (2008), the Scottish Intercollegiate Guidelines Network (SIGN) (2009) and the British National Formulary for Children (BNFC). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Israel | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 64 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 10 | 15% |
Student > Bachelor | 10 | 15% |
Researcher | 7 | 10% |
Student > Doctoral Student | 5 | 7% |
Student > Ph. D. Student | 5 | 7% |
Other | 13 | 19% |
Unknown | 17 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 25% |
Psychology | 15 | 22% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 7% |
Computer Science | 2 | 3% |
Nursing and Health Professions | 2 | 3% |
Other | 4 | 6% |
Unknown | 22 | 33% |