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Characterization of adipocyte differentiation from human mesenchymal stem cells in bone marrow

Overview of attention for article published in BMC Developmental Biology, May 2010
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Title
Characterization of adipocyte differentiation from human mesenchymal stem cells in bone marrow
Published in
BMC Developmental Biology, May 2010
DOI 10.1186/1471-213x-10-47
Pubmed ID
Authors

Shu-Wen Qian, Xi Li, You-You Zhang, Hai-Yan Huang, Yuan Liu, Xia Sun, Qi-Qun Tang

Abstract

Adipocyte hyperplasia is associated with obesity and arises due to adipogenic differentiation of resident multipotent stem cells in the vascular stroma of adipose tissue and remote stem cells of other organs. The mechanistic characterization of adipocyte differentiation has been researched in murine pre-adipocyte models (i.e. 3T3-L1 and 3T3-F442A), revealing that growth-arrest pre-adipocytes undergo mitotic clonal expansion and that regulation of the differentiation process relies on the sequential expression of three key transcription factors (C/EBPbeta, C/EBPalpha and PPARgamma). However, the mechanisms underlying adipocyte differentiation from multipotent stem cells, particularly human mesenchymal stem cells (hBMSCs), remain poorly understood. This study investigated cell cycle regulation and the roles of C/EBPbeta, C/EBPalpha and PPARgamma during adipocyte differentiation from hBMSCs.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 180 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 3%
Gambia 1 <1%
Austria 1 <1%
Spain 1 <1%
Czechia 1 <1%
Japan 1 <1%
Luxembourg 1 <1%
Unknown 168 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 48 27%
Researcher 34 19%
Student > Master 31 17%
Student > Bachelor 16 9%
Professor > Associate Professor 8 4%
Other 25 14%
Unknown 18 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 80 44%
Biochemistry, Genetics and Molecular Biology 31 17%
Medicine and Dentistry 17 9%
Engineering 6 3%
Chemistry 5 3%
Other 14 8%
Unknown 27 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 January 2012.
All research outputs
#15,241,259
of 22,661,413 outputs
Outputs from BMC Developmental Biology
#258
of 369 outputs
Outputs of similar age
#77,332
of 95,041 outputs
Outputs of similar age from BMC Developmental Biology
#5
of 7 outputs
Altmetric has tracked 22,661,413 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 369 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 95,041 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.