Title |
Characterization of adipocyte differentiation from human mesenchymal stem cells in bone marrow
|
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Published in |
BMC Developmental Biology, May 2010
|
DOI | 10.1186/1471-213x-10-47 |
Pubmed ID | |
Authors |
Shu-Wen Qian, Xi Li, You-You Zhang, Hai-Yan Huang, Yuan Liu, Xia Sun, Qi-Qun Tang |
Abstract |
Adipocyte hyperplasia is associated with obesity and arises due to adipogenic differentiation of resident multipotent stem cells in the vascular stroma of adipose tissue and remote stem cells of other organs. The mechanistic characterization of adipocyte differentiation has been researched in murine pre-adipocyte models (i.e. 3T3-L1 and 3T3-F442A), revealing that growth-arrest pre-adipocytes undergo mitotic clonal expansion and that regulation of the differentiation process relies on the sequential expression of three key transcription factors (C/EBPbeta, C/EBPalpha and PPARgamma). However, the mechanisms underlying adipocyte differentiation from multipotent stem cells, particularly human mesenchymal stem cells (hBMSCs), remain poorly understood. This study investigated cell cycle regulation and the roles of C/EBPbeta, C/EBPalpha and PPARgamma during adipocyte differentiation from hBMSCs. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 6 | 3% |
Gambia | 1 | <1% |
Austria | 1 | <1% |
Spain | 1 | <1% |
Czechia | 1 | <1% |
Japan | 1 | <1% |
Luxembourg | 1 | <1% |
Unknown | 168 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 48 | 27% |
Researcher | 34 | 19% |
Student > Master | 31 | 17% |
Student > Bachelor | 16 | 9% |
Professor > Associate Professor | 8 | 4% |
Other | 25 | 14% |
Unknown | 18 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 80 | 44% |
Biochemistry, Genetics and Molecular Biology | 31 | 17% |
Medicine and Dentistry | 17 | 9% |
Engineering | 6 | 3% |
Chemistry | 5 | 3% |
Other | 14 | 8% |
Unknown | 27 | 15% |