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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Caspase-Mediated Apoptosis in Neuronal Excitotoxicity Triggered by Nitric Oxide
|
|---|---|
| Published in |
Molecular Medicine, November 1997
|
| DOI | 10.1007/bf03401713 |
| Pubmed ID | |
| Authors |
Marcel Leist, Christiane Volbracht, Simone Kühnle, Eugenio Fava, Elisa Ferrando-May, Pierluigi Nicotera |
| Abstract |
Excitotoxicity and excess generation of nitric oxide (NO) are believed to be fundamental mechanisms in many acute and chronic neurodegenerative disorders. Disturbance of Ca2+ homeostasis and protein nitration/nitrosylation are key features in such conditions. Recently, a family of proteases collectively known as caspases has been implicated as common executor of a variety of death signals. In addition, overactivation of poly-(ADP-ribose) polymerase (PARP) has been observed in neuronal excitotoxicity. We therefore designed this study to investigate whether triggering of caspase activity and/or activation of PARP played a role in cerebellar granule cell (CGC) apoptosis elicited by peroxynitrite (ONOO-) or NO donors. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 5% |
| Unknown | 39 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 29% |
| Researcher | 8 | 20% |
| Other | 3 | 7% |
| Student > Doctoral Student | 2 | 5% |
| Lecturer | 2 | 5% |
| Other | 7 | 17% |
| Unknown | 7 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 22% |
| Biochemistry, Genetics and Molecular Biology | 7 | 17% |
| Neuroscience | 7 | 17% |
| Medicine and Dentistry | 3 | 7% |
| Psychology | 1 | 2% |
| Other | 3 | 7% |
| Unknown | 11 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2012.
All research outputs
#20,660,571
of 25,382,440 outputs
Outputs from Molecular Medicine
#967
of 1,206 outputs
Outputs of similar age
#28,268
of 29,630 outputs
Outputs of similar age from Molecular Medicine
#10
of 10 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,206 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 29,630 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 2nd percentile – i.e., 2% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one.