Title |
Reduction of parathyroid hormone with vitamin D supplementation in blacks: a randomized controlled trial
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Published in |
BMC Nutrition, December 2015
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DOI | 10.1186/s40795-015-0024-8 |
Pubmed ID | |
Authors |
Paulette D. Chandler, Foluso Agboola, Kimmie Ng, Jamil B. Scott, Bettina F. Drake, Gary G. Bennett, Andrew T. Chan, Bruce W. Hollis, Karen M. Emmons, Charles S. Fuchs, Edward L. Giovannucci |
Abstract |
Response of parathyroid hormone (PTH) to vitamin D supplementation is determined by the baseline PTH level and change in vitamin D status. Conflicting reports in Blacks exist on the PTH response to vitamin D to supplementation. During 3 winters from 2007-2010, 328 healthy Blacks (median age, 51 years) living in Boston, MA were randomized into a 4-arm, double-blind trial for 3 months of placebo, 1000, 2000, or 4000 IU of vitamin D3. PTH was measured in 254 participants at baseline and at the end of vitamin D supplementation period. The differences in PTH between baseline and 3 months were 3.93 pg/mL for those receiving placebo, -3.37 pg/mL for those receiving 1000 IU/d, -6.76 pg/mL for those receiving 2000 IU/d, and -8.99 pg/mL for those receiving 4000 IU/d ( -2.98 pg/mL for each additional 1000 IU/d of vitamin D3; p<0.001). We found a significant decrease in PTH with increasing doses of vitamin D supplementation up to intakes of 4000 IU/d in Blacks. Clinical Trials.gov: NCT00585637. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 3 | 20% |
Student > Bachelor | 2 | 13% |
Professor | 2 | 13% |
Student > Master | 2 | 13% |
Student > Ph. D. Student | 1 | 7% |
Other | 2 | 13% |
Unknown | 3 | 20% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 5 | 33% |
Nursing and Health Professions | 3 | 20% |
Agricultural and Biological Sciences | 1 | 7% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Unknown | 5 | 33% |