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Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice

Overview of attention for article published in Molecular Neurodegeneration, December 2011
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Title
Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice
Published in
Molecular Neurodegeneration, December 2011
DOI 10.1186/1750-1326-6-87
Pubmed ID
Authors

Ping Gong, Jelita Roseman, Celia G Fernandez, Kulandaivelu S Vetrivel, Vytautas P Bindokas, Lois A Zitzow, Satyabrata Kar, Angèle T Parent, Gopal Thinakaran

Abstract

p23 belongs to the highly conserved p24 family of type I transmembrane proteins, which participate in the bidirectional protein transport between the endoplasmic reticulum and Golgi apparatus. Mammalian p23 has been shown to interact with γ-secretase complex, and modulate secretory trafficking as well as intramembranous processing of amyloid precursor protein in cultured cells. Negative modulation of β-amyloid production by p23 in cultured cell lines suggested that elevation of p23 expression in neurons might mitigate cerebral amyloid burden.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 35 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 26%
Student > Bachelor 5 14%
Student > Master 4 11%
Researcher 3 9%
Student > Postgraduate 2 6%
Other 5 14%
Unknown 7 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 17%
Biochemistry, Genetics and Molecular Biology 5 14%
Neuroscience 5 14%
Medicine and Dentistry 5 14%
Psychology 3 9%
Other 4 11%
Unknown 7 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2012.
All research outputs
#18,303,566
of 22,661,413 outputs
Outputs from Molecular Neurodegeneration
#780
of 842 outputs
Outputs of similar age
#195,774
of 243,691 outputs
Outputs of similar age from Molecular Neurodegeneration
#16
of 22 outputs
Altmetric has tracked 22,661,413 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 842 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,691 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.